Results 71 to 80 of about 1,171,002 (301)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Global precipitation climatology

, 2012
This visualziation shows the monthly mean precipitation around the globe from 1979 - 2008. Data was provided by the NOAA Cooperative Institute for Climate Studies at the University of MarylandEducação Superior::Ciências Exatas e da Terra ...
National Oceanic and Atmospheric Administration
core   +2 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Precipitation averaged across Europe, GPCC, 1914-1920 C.E.

DATA DESCRIPTION: Precipitation averaged across Europe, GPCC, 1914-1920 Citation: Alexander F. More, Christopher P. Loveluck, Heather Clifford, Michael J. Handley, Elena V. Korotkikh, Andrei V. Kurbatov, Michael McCormick and Paul A. Mayewski. (2020).
Global Precipitation Climatology Centre
core   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

The Importance of Humidity in the Afternoon Local-Scale Precipitation Intensity over Eastern China and Its Impacts on the Aerosol Effects

Remote Sensing
Thermally driven local-scale precipitation (LSP) is an important type of summer precipitation over China, but the prestorm environmental conditions remain unclear.
Xinlei Tang, Qian Chen, Jianping Guo, Jing Yang, Zeyong Zou, Jinghua Chen, Yue Sun   +6 more
doaj   +1 more source

Relative roles of aerosol size and hygroscopicity in modulating marine liquid-phase cloud responses under the winter monsoon [PDF]

Atmospheric Chemistry and Physics
How aerosol physicochemical properties affect aerosol-cloud interactions (ACI) and when these impacts are most pronounced represent an important source of ACI uncertainty.
J. Zhao, J. Zhao, X. Ma, H. Jia, T. Yang, P. Zou, Y. Ku   +6 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source