Results 61 to 70 of about 1,064,125 (299)

Role of Hydrodynamics, Li⁺ Addition and Transformation Kinetics on the Formation of Plate-Like {001} Calcite Crystals

Crystals, 2021
Plate-like calcite crystals with expressed unstable {001} planes are interesting research model for investigations of interfacial interactions of different additive molecules, but also the crystal growth mechanisms.
Nives Matijaković Mlinarić, Jasminka Kontrec, Branka Njegić Džakula, Giuseppe Falini, Damir Kralj   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Substorm related changes in precipitation in the dayside auroral zone-a multi instrument case study [PDF]

, 2002
International audienceA period (08:10?14:40 MLT, 11 February 1997) of enhanced electron density in the D- and E-regions is investigated using EISCAT, IRIS and other complementary instruments.
J. Manninen (7637285), E. Donovan (7591466), I. W. McCrea, Honary, F., Manninen, J., P. C. Anderson, A. J. Kavanagh (7614089), F. Honary (7604621), E. Donovan, I. W. McCrea (7594871), Kavanagh, A. J., A. J. Kavanagh, P. C. Anderson (7637288), McCrea, I. W., F. Honary, J. Manninen, E. E. Woodfield (7590071), E. E. Woodfield, Donovan, E., Woodfield, E. E., Anderson, P. C.   +20 more
core   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Precipitation Induced Signatures in SAR Images [PDF]

, 2009
Active microwave SAR imaging of the Earth’s surface is commonly considered to be of all weather capability. However, as the operating frequencies of SAR-systems are increasing, visible image distortions due to heavy precipitation in SAR-images are ...
Chandra, Madhu, Danklmayer, Andreas
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A Composite Approach for Evaluating Operational Cloud Seeding Effect in Stratus Clouds

Hydrology
Robust water management is in intense demand in many water scarcity areas, such as arid and semi-arid regions in the world. As part of the regional water management strategy, rain enhancement is vital to replenish groundwater reservoirs, and the key ...
Fei Wang, Baojun Chen, Zhiguo Yue, Jin Wang, Dejun Li, Dawei Lin, Yahui Tang, Tian Luan   +7 more
doaj   +1 more source

Influence of the Background Nitrogen Oxides on the Tropospheric Ozone Depletion Events in the Arctic during Springtime

Atmosphere, 2020
Ozone depletion events (ODEs) in the springtime of the Arctic have been frequently observed since the early 1980s, and the correlation between the ozone mixing ratio during the ODEs and the nitrogen oxides (NOx) concentration is still unclear.
Jiashu Zhou, Le Cao, Simeng Li
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source