Results 51 to 60 of about 1,773,542 (300)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Aircraft Observations of Ice Particle Properties in Stratiform Precipitating Clouds

Advances in Meteorology, 2014
This study presented airborne measurements of ice particle properties in three stratiform precipitating clouds over northern China. By using horizontal observations at selected altitudes, the distributions of ice water content (IWC), particle habits, and
Tuanjie Hou, Hengchi Lei, Zhaoxia Hu, Jun Zhou   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Optimal Ranking Regime Analysis of Intra- to Multidecadal U.S. Climate Variability. Part II: Precipitation and Streamflow [PDF]

, 2014
In Part I of this paper, the optimal ranking regime (ORR) method was used to identify intradecadal to multidecadal (IMD) regimes in U.S. climate division temperature data during 1896–2012.
Cordero, Eugene C., Mauget, Steven A.
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A Uniformity Index for Precipitation Particle Axis Ratios Derived from Radar Polarimetric Parameters for the Identification and Analysis of Raindrop Areas

Remote Sensing, 2023
A uniformity index for the axis ratios (Uar) derived from dual polarization weather radar data is proposed for raindrop area identification and analysis. The derivation of this new parameter is based on radar scattering simulations and assumptions.
Yue Sun, Hui Xiao, Huiling Yang, Haonan Chen, Liang Feng, Weixi Shu, Han Yao   +6 more
doaj   +1 more source

Improving Precipitation Estimation Using Convolutional Neural Network [PDF]

, 2019
Precipitation process is generally considered to be poorly represented in numerical weather/climate models. Statistical downscaling (SD) methods, which relate precipitation with model resolved dynamics, often provide more accurate precipitation estimates
AghaKouchak, A, Hsu, K, Pan, B, Sorooshian, S   +3 more
core  

A simple reactive-transport model of calcite precipitation in soils and other porous media [PDF]

, 2015
Calcite formation in soils and other porous media generally occurs around a localised source of reactants, such as a plant root or soil macro-pore, and the rate depends on the transport of reactants to and from the precipitation zone as well as the ...
Kirk, Guy J. D., Milodowski, A. E., Ritz, K., Versteegen, A.   +3 more
core   +1 more source

Influence of Sea-Ice Anomalies on Antarctic Precipitation Using Source Attribution in the Community Earth System Model [PDF]

, 2020
We conduct sensitivity experiments using a general circulation model that has an explicit water source tagging capability forced by prescribed composites of pre-industrial sea-ice concentrations (SICs) and corresponding sea surface temperatures (SSTs) to
Fyke, Jeremy G., Lenaerts, Jan T. M., Noone, David, Nusbaumer, Jesse M., Rasch, Philip J., Singh, Hansi, Wang, Hailong, Zhang, Rudong   +7 more
core   +3 more sources