Results 61 to 70 of about 4,573 (258)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

ACCURACY OF SATELLITE OPTICAL OBSERVATIONS AND PRECISE ORBIT DETERMINATION

Odessa Astronomical Publications, 2017
The  monitoring  of  low-orbit  space  objects (LEO-objects) is performed in the Astronomical Observatory  of  Odessa  I.I. Mechnikov  National  University (Ukraine) for many years.
L. Shakun, N. Koshkin, E. Korobeynikova, S. Strakhova, V. Dragomiretsky, A. Ryabov, S. Melikyants, T. Golubovskaya, S. Terpan   +8 more
doaj   +1 more source

Precise Orbit Determination of LEO Satellite Using Dual-Frequency GPS Data [PDF]

Journal of Astronomy and Space Sciences, 2009
KOrea Multi-purpose SATellite (KOMPSAT)-5 will be launched at 550km altitude in 2010. Accurate satellite position (20 cm) and velocity (0.03 cm/s) are required to treat highly precise Synthetic Aperture Radar (SAR) image processing.
Yoola Hwang, Byoung-Sun Lee, Jaehoon Kim, Jae-Cheol Yoon   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Overview on Space-Based Optical Orbit Determination Method Employed for Space Situational Awareness: From Theory to Application

Photonics
Leveraging space-based optical platforms for space debris and defunct spacecraft detection presents several advantages, including a wide detection range, immunity to cloud cover, and the ability to maintain continuous surveillance on space targets.
Zhe Zhang, Gaopeng Zhang, Jianzhong Cao, Cheng Li, Weining Chen, Xin Ning, Zheng Wang   +6 more
doaj   +1 more source

Real-Time Orbit Determination of Korean Navigation Satellite System based on Multi-GNSS Precise Point Positioning [PDF]

E3S Web of Conferences, 2019
This study proposes real-time orbit/clock determination of Korean Navigation Satellite System (KNSS), which employs the kinematic precise point positioning (PPP) solutions of multiple Global Navigation Satellite System (multi-GNSS) to compensate for ...
Kim Gimin, Oh Hyungjik, Park Chandeok, Seo Seungmo   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source