Results 41 to 50 of about 1,922,046 (318)
Precision Engineering behind European Astronomy Programmes [PDF]
, 2011 The fields of astronomy science have presented significant precision engineering challenges. Numerous solutions for these fields of science have achieved unprecedented levels of accuracy, sensitivity and sheer scale.
Shore, Paul, Tonnellier, Xavier
core
Journal of Intelligent SystemsAs the number of online news texts continues to increase, the algorithm of automatic keyword extraction becomes a key content in facilitating users’ fast access to the desired content.
Wang Yan
doaj +1 more source
AMA Journal of Ethics, 2018 The Precision Portrait is a mixed-media portrait illustrating the future of precision medicine and its ethical challenges.
Samuel, Rodriguez, Nick, Love
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Precision Muonium Spectroscopy [PDF]
, 2016 The muonium atom is the purely leptonic bound state of a positive muon and an electron. It has a lifetime of 2.2 mu s. The absence of any known internal structure provides for precision experiments to test fundamental physics theories and to determine ...
Jungmann, Klaus P.; id_orcid +1 more
core +1 more source
Is Precision Therapy in Infantile-Onset Epileptic Encephalopathies Still Too Far to Call Upon?
Applied SciencesEpileptic and developmental encephalopathies (EDEs) are a group of severe, genetically various neurological conditions characterized by early-onset seizures and developmental impairments.
Raffaele Falsaperla +2 more
doaj +1 more source
From precision interventions to precision health
Nature CommunicationsAbstract Precision medicines, or those medicines that are tailored to individual genetic, molecular, physiologic, behavioral, and/or exposure profiles, are being developed at a rapid pace. However, just how precise these interventions are in terms of their mechanisms of action (MOAs), clinical effects, and utility in different individuals ...
Nicholas J. Schork, Laura H. Goetz
openaire +3 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source