Results 61 to 70 of about 2,235,945 (303)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

External Quality Assurance Scheme as a tool for evaluating laboratory performance in a tertiary care hospital [PDF]

Medical Laboratory Journal
Background: Quality control (QC) is a crucial tool in the clinical laboratory for error identification and correction. While the Internal Quality Control (IQC) ensures daily precision and accuracy, the External Quality Assurance Scheme (EQAS) ensures ...
Supriya Gulajkar, Rajni Shivkar, Sanjyoti Panchbudhe, Charushila Kadam   +3 more
doaj  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

An Examination of the Effectiveness of Precision Teaching [PDF]

, 2009
This research examined the effect of adding precision teaching to an already used method of times table practice, compared practice with and without precision teaching, and finally compared precision teaching to rate building.
McQuarters, Desiree Julia Bettina
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Defect identification algorithm for weld X-ray imagesbased on the CCBFE-RCNN model

Hanjie xuebao
In view of the problems of high labor intensity and low detection efficiency in the manual evaluation process of X-ray images, a multi-scale object detection network CCBFE-RCNN model based on the improved Cascade-RCNN network is proposed.
Zheng DAI, Xiaojia LIU, Quan PAN
doaj   +1 more source

1-s Productions: A Validation of an Efficient Measure of Clock Variability

Frontiers in Human Neuroscience, 2018
Objective: Clock variance is an important statistic in many clinical and developmental studies. Existing methods require a large number of trials for accurate clock variability assessment, which is problematic in studies using clinical or either young or
Sarah C. Maaß, Sarah C. Maaß, Hedderik van Rijn   +2 more
doaj   +1 more source

From precision interventions to precision health

Nature Communications
Abstract Precision medicines, or those medicines that are tailored to individual genetic, molecular, physiologic, behavioral, and/or exposure profiles, are being developed at a rapid pace. However, just how precise these interventions are in terms of their mechanisms of action (MOAs), clinical effects, and utility in different individuals ...
Nicholas J. Schork, Laura H. Goetz
openaire   +3 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source