Results 71 to 80 of about 1,337,793 (267)
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Precision and False Perceptual Inference
Frontiers in Integrative Neuroscience, 2018 Accurate perceptual inference fundamentally depends upon accurate beliefs about the reliability of sensory data. In this paper, we describe a Bayes optimal and biologically plausible scheme that refines these beliefs through a gradient descent on ...
Thomas Parr +3 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Cleveland Clinic Journal of Medicine, 2020 ![][1] The concept of “precision medicine” includes the ability to prospectively determine how best to provide the right therapy to the right patient to treat the right disease. The goal of providing tailored treatment is not a new concept. It is the cornerstone of all therapies,
openaire +2 more sources
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Precision medicine: precision viticulture [PDF]
Bone Marrow Transplantation, 2022 openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Sensors, 2018 Kinematic laser scanning with moving platforms has been used for the acquisition of 3D point clouds of our environment for many years. A main application of these mobile systems is the acquisition of the infrastructure, e.g., the road surface and ...
Erik Heinz +3 more
doaj +1 more source
What Precisely Is Precision Medicine? [PDF]
Trends in Pharmacological Sciences, 2017 In some ways, precision has been a goal for medicine since its first inception. Swallow this herb for a headache, but rub that poultice on a sore foot. Different ailments, everyone realized, require tailored treatments to be effective. As understanding of biological complexity improved, especially with the breakthrough of genetic sequencing, we gained ...
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FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source