Results 91 to 100 of about 2,235,945 (303)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

RISK MANAGEMENT POTENTIAL OF PRECISION FARMING TECHNOLOGIES [PDF]

Initial ideas on risk management uses of precision agricultural technology focused on site-specific treatment of problem areas to reduce the probability of low yields and returns.
Lowenberg-DeBoer, James
core  

Precision and False Perceptual Inference

Frontiers in Integrative Neuroscience, 2018
Accurate perceptual inference fundamentally depends upon accurate beliefs about the reliability of sensory data. In this paper, we describe a Bayes optimal and biologically plausible scheme that refines these beliefs through a gradient descent on ...
Thomas Parr, David A. Benrimoh, Peter Vincent, Karl J. Friston   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Precision medicine: precision viticulture [PDF]

Bone Marrow Transplantation, 2022
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Precision luminosity measurements at LHCb [PDF]

, 2014
Measuring cross-sections at the LHC requires the luminosity to be determined accurately at each centre-of-mass energy root s. In this paper results are reported from the luminosity calibrations carried out at the LHC interaction point 8 with the LHCb ...
Pescatore, L., Beaucourt, L., Baldini, W., Barschel, C., Barsuk, S., Alexander, M., Ajaltouni, Z., Amerio, S., Aaij, R., Anderlini, L., Williams, M. P., Kenyon, I. R., Bachmann, S., Barlow, R. J., Alves, A. A., Alkhazov, G., Battista, V., Baesso, C., Onderwater, C. J. G., Cartelle, P. Alvarez, Bedeschi, F., Belous, K., Mazurov, A., Artuso, M., An, L., Gutierrez, O. Aquines, Ali, S., Auriemma, G., Artamonov, A., Alves, Jr A., Archilli, F., Lazzeroni, C., Appleby, R. B., Beddow, J., Bediaga, I., Adeva, B., Affolder, A., Andreassen, R., Batozskaya, V., Anderson, J., Baalouch, M., Bifani, S., McCarthy, J., Onderwater, C. J. G.; id_orcid, Badalov, A., Watson, N. K.; id_orcid, Barter, W., Belogurov, S., Andrews, J. E., Griffith, P., Adinolfi, M., Aslanides, E., Farley, N., Andreotti, M., Amato, S., Akar, S., Alessio, F., Bay, A., Albrecht, J., Alvarez Cartelle, P., Amhis, Y., Back, J. J., Pellegrino, A., Parkinson, C. J.   +63 more
core   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Strategy for Determining the Stochastic Distance Characteristics of the 2D Laser Scanner Z + F Profiler 9012A with Special Focus on the Close Range

Sensors, 2018
Kinematic laser scanning with moving platforms has been used for the acquisition of 3D point clouds of our environment for many years. A main application of these mobile systems is the acquisition of the infrastructure, e.g., the road surface and ...
Erik Heinz, Markus Mettenleiter, Heiner Kuhlmann, Christoph Holst   +3 more
doaj   +1 more source