Results 81 to 90 of about 3,951,204 (287)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Precision N-glycoproteomics reveals the essential role of the extracellular matrix in tropomyosin allergy in a mouse model

Food Science and Human Wellness
Approximately 2.5% of the global population experience allergic reactions to seafood, making it one of the most prevalent and life-threatening allergies.
Guirong Liu, Qianwei Wang, Yibo Luo, Lijuan Sun, Ruolin Song, Huilian Che, Changqi Liu, Xiaohui Guo   +7 more
doaj   +1 more source

Precision medicine: precision viticulture [PDF]

Bone Marrow Transplantation, 2022
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The precision principle: driving biological self-organization

Frontiers in Network Physiology
In this perspective, we introduce the Precision Principle as a unifying theoretical framework to explain self-organization across biological systems.
Raymond Roy, Raymond Roy, Kiranpreet Sidhu, Kiranpreet Sidhu, Gabriel Byczynski, Amedeo D’Angiulli, Amedeo D’Angiulli, Birgitta Dresp-Langley   +7 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Precision evaluation of 2 CT-based radiostereometric analysis systems in a cadaver study

Acta Orthopaedica
Background and purpose: To address the limitations of radiostereometric imaging and to eliminate the need for intraoperative marker placement, CT-based radiostereometric analysis (CT-RSA) software systems have been developed.
Maaike R de Bondt, Frank-David Øhrn, Lars H W Engseth, Anselm Schulz, Bart L Kaptein, Stephan M Röhrl, Petra J C Heesterbeek   +6 more
doaj   +1 more source

Automated precision passing system [PDF]

, 2014
Athletes are always seeking ways to improve their performance. Down time and a lack of capable throwers prevent athletic receivers from practicing their skills.
Herrera, Bryan, Raffaeli, Mikiah, Savitz, David   +2 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source