Results 101 to 110 of about 3,951,204 (287)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

You Don’t Bend It Like Beckham if You’re Female and Reminded of It: Stereotype Threat Among Female Football Players

Frontiers in Psychology, 2019
Originally, the stereotype threat effect – poorer performance due to a fear of fulfilling a negative stereotype about one’s group – was demonstrated for cognitive tasks (e.g. Steele and Aronson, 1995, or Steele, 1997).
Hilmar Grabow, Melanie Kühl
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Early detection and classification of Alzheimer’s disease through data fusion of MRI and DTI images using the YOLOv11 neural network

Frontiers in Neuroscience
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia worldwide, affecting over 55 million people globally, with numbers expected to rise dramatically.
Wided Hechkel, Abdelhamid Helali
doaj   +1 more source

ARTIFICIAL INTELLIGENCE IN BUSINESS OPERATIONS: EXPLORING PRODUCTIVITY AND ACCEPTANCE [PDF]

Annals of the University of Oradea: Economic Science
This paper will provide information on the impact of AI in daily life and work-related activities.Today, AI functionalities could nowadays transform businesses, playing a critical role in enhancing and improving decisions.
Ioana CIOFU, Giulia KONDORT, Stefana POP, Roxana CIOC   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Performance Evaluation of a B-type Natriuretic Peptide Assay Using the Alinity i Analyzer

Korean Journal of Clinical Laboratory Science
B-type natriuretic peptide (BNP) is a crucial cardiac biomarker secreted from the ventricles in response to volume and pressure overload that is used widely in the diagnosis, prognosis, and risk assessments of heart failure.
Jae Yoon LEE, Chan Kyu KIM, Gi Yeong KIM, Kyung Sook CHOI, Ho Keun CHOI   +4 more
doaj   +1 more source

Comparative analysis of Access PCT and Elecsys BRAHMS PCT assays for procalcitonin measurements [PDF]

Kosin Medical Journal
Background Procalcitonin (PCT) is a crucial biomarker for diagnosing sepsis and managing antibiotic therapy. This study evaluated the analytical performance and comparability of the Access PCT and Elecsys BRAHMS PCT assays.
Hyunji Choi, Sang-Shin Lee, Hyunyong Hwang   +2 more
doaj   +1 more source