Results 101 to 110 of about 2,235,945 (303)
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Sensors, 2012 The increased variations of temporal gait events when pathology is present are good candidate features for objective diagnostic tests. We hypothesised that the gait events hoof-on/off and stance can be detected accurately and precisely using features ...
Thilo Pfau +2 more
doaj +1 more source
What Precisely Is Precision Medicine? [PDF]
Trends in Pharmacological Sciences, 2017 In some ways, precision has been a goal for medicine since its first inception. Swallow this herb for a headache, but rub that poultice on a sore foot. Different ailments, everyone realized, require tailored treatments to be effective. As understanding of biological complexity improved, especially with the breakthrough of genetic sequencing, we gained ...
openaire +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
An Economic analysis of the potential for precision farming in UK cereal production [PDF]
, 2003 The results from alternative spatial nitrogen application studies are analysed in economic terms and compared to the costs of precision farming hardware, software and other services for cereal crops in the UK.
Welsh, J. P. +4 more
core +1 more source
Activity at IPT in precision engineering
, 2022 Precision Engineering is a grouping of multidisciplinary scientific and engineering techniques including dimensional metrology, high precision machine design, process technology, microengineering and nanotechnology.
Luderich, Jörg, Weck, Manfred
core +1 more source
Sensors, 2018 Digital hemispherical photography (DHP) has been widely used to estimate leaf area index (LAI) in forestry. Despite the advancement in the processing of hemispherical images with dedicated tools, several steps are still manual and thus easily affected by
Carlo Gilardelli +3 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source