Results 101 to 110 of about 3,580,467 (256)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Realization of a compact mercury ion microwave clock with frequency stability of 6.3 × 10− 16

Scientific Reports
The mercury ion microwave clock is considered to be one of the leading candidates for new generation satellite navigation atomic clocks due to its excellent long-term frequency stability, extremely low frequency drift rate, high reliability and good ...
Hao Liu, Yihe Chen, Jian Wang, Shuhong Huang, Longbao Xiang, Shicheng Yu, Chengbin Li, Lijun Du, Lei She   +8 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Analysis of the Dick Effect for AI-Based Dynamic Gravimeters

Sensors
Atom interferometer (AI)-based dynamic gravimeters enable high-precision absolute gravity measurements, which are crucial for applications in geophysics, navigation, resource exploration, and metrology.
Wen-Zhang Wang, Xi Chen, Jin-Ting Li, Dan-Fang Zhang, Wei-Hao Xu, Jia-Yi Wei, Jia-Qi Zhong, Biao Tang, Lin Zhou, Jin Wang, Ming-Sheng Zhan   +10 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Orthogonal distance fitting of precision free form surfaces based on l1 norm [PDF]

, 2008
Precision free-form surfaces are widely used in advanced optical and mechanical devices. In order to evaluate the form quality of a free-form surface, it is required to fit the measurement data with the design template and compare the relative deviation ...
Zhang, Xiangchao, Jiang, Xiang, Scott, Paul J.   +2 more
core   +2 more sources

Adaptive Curved Slicing for En Face Imaging in Optical Coherence Tomography

Sensors
Optical coherence tomography (OCT) employs light to acquire high-resolution 3D images and is widely applied in fields such as ophthalmology and forensic science.
Mingxin Li, Phatham Loahavilai, Yueyang Liu, Xiaochen Li, Yang Li, Liqun Sun   +5 more
doaj   +1 more source

Enhanced-Precision Measurement of Glutathionyl Hemoglobin by MALDI-ToF MS. [PDF]

Molecules, 2023
Rubino FM, Ottolenghi S, Brizzolari A, Maioli C, Samaja M, Paroni R.   +5 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Precision Measurement of the Return Distribution Property of the Chinese Stock Market Index. [PDF]

Entropy (Basel), 2022
Liu P, Zheng Y.
europepmc   +1 more source