Results 101 to 110 of about 507,954 (312)

Design, Fabrication, Characterization, and Application of an Ultra-High Temperature 6H-SiC Sapphire Fiber Optic Vibration Sensor

IEEE Photonics Journal, 2019
A 6H-SiC Sapphire fiber optic vibration sensor that can work at 1200 °C was designed, fabricated and tested in this paper. A sapphire fiber and a 6H-SiC vibration-sensitive element constituted the Fabry–Perot resonant cavity.
Yigang Huang, Fei Tang, Dawei Ma, Zhenjun Liu, Xiaohao Wang   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

High precision size measurement system of industrial profiles section

, 2015
This paper implements a non-contact measurement system based on machine vision for industrial profiles section, which uses double telecentric lens optical system as image acquisition device. The key procedures using double telecentric lens optical system
Zhang YC(张宜弛), Wu Y(吴阳), Zhou XF(周晓锋), Li S(李帅)   +3 more
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Multiple frequency range imaging to remove measurement ambiguity

, 2009
Range imaging systems use a specialised sensor to capture an image where object distance (range) is measured for every pixel using time-of-flight. The scene is illuminated with an amplitude modulated light source, and the phase of the modulation envelope
Payne, Andrew D., Dorrington, Adrian A., Jongenelen, Adrian P.P., Carnegie, Dale A., Cree, Michael J.   +4 more
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Four-Dimensional Thermal Analysis of 888 nm Pumped Nd:YVO4 Dual-Rod Acousto-Optic Q-Switched Laser

Applied Sciences, 2017
A theoretical analysis upon the four-dimensional (4D) spatio-temporal temperature dependent dynamics of 888 nm pumped Nd:YVO 4 dual-rod laser is established, which is valid in both continuous-wave (CW) and acousto-optic (AO) Q-switched pulse ...
Yijie Shen, Wenqi Zhang, Mali Gong, Yuan Meng, Yunbin Wang, Xing Fu   +5 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

LNE Activies in Nanometrology: flatness reference calibration algorithm [PDF]

, 2008
The Laboratoire National de Métrologie et d’Essais (LNE) has developed an innovative ultra precision coordinate measuring machine [LAH07] traceable to the national length standard to measure three-dimensional objects with nanometric uncertainties (figure
LAHOUSSE, Ludovic, LELEU, Stéphane, BORIPATKOSOL, Siriwan, DAVID, Jean-Marie, GIBARU, Olivier, COOREVITS, Thierry, DUCOURTIEUX, Sébastien   +6 more
core