Results 111 to 120 of about 446,257 (263)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Real-time facial micromotion tracking enabled by an ultrathin silk fibroin patch
Microsystems & NanoengineeringDriven by the rapid development of green wearable electronics, increasing attention has been directed toward environmentally sustainable and biocompatible piezoelectric devices based on natural biomaterials. Nevertheless, the inherently low piezoelectric
Qi Li +7 more
doaj +1 more source
Every gene everywhere all at once: High-precision measurement of 3D chromosome architecture with single-cell Hi-C. [PDF]
Front Mol Biosci, 2022 Chi Y, Shi J, Xing D, Tan L.
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Interferometric scattering for optical tomoslicing of transparent solids
Light: Science & ApplicationsWhile light scattering is widely utilized in optical metrology and measurement, it has long been regarded as detrimental in laser-material processing. Here, we report an interferometric scattering effect that overturns this conventional view by resolving
Yuan Chai +9 more
doaj +1 more source
K-Schedules Meet Precision Measurement: A Protocol for Intervention. [PDF]
Behav Anal Pract, 2021 Milyko K.
europepmc +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Correction to: K-Schedules Meet Precision Measurement: A Protocol for Intervention. [PDF]
Behav Anal Pract, 2021 Milyko K.
europepmc +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Precision measurement of electron-electron scattering in GaAs/AlGaAs using transverse magnetic focusing. [PDF]
Nat Commun, 2021 Gupta A +6 more
europepmc +1 more source