Results 51 to 60 of about 3,580,467 (256)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Precision measurement of D meson mass differences [PDF]

open access: yes, 2013
Using three- and four-body decays of D mesons produced in semileptonic b-hadron decays, precision measurements of D meson mass differences are made together with a measurement of the D 0 mass.
Hennessy K.   +999 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

An ultralight, tiny, flexible six-axis force/torque sensor enables dexterous fingertip manipulations

open access: yesNature Communications
Multi-dimensional mechanoreceptors are crucial for both humans and robots, providing omnidirectional force/torque senses to ensure dexterous and precise manipulations.
Qian Mao   +4 more
doaj   +1 more source

Cascaded Dual-Soliton Pulse Stokes for Broadband Coherent Anti-Stokes Raman Spectroscopy

open access: yesIEEE Photonics Journal, 2016
We report a spectrally and temporally cascaded dual-soliton Stokes excitation source for broadband coherent anti-Stokes Raman spectroscopy (CARS) based on a single Yb-doped fiber laser.
Kun Chen   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

High-Precision Measurement of Sine and Pulse Reference Signals Using Software-Defined Radio

open access: yes, 2022
S.1132-1141This paper addresses simultaneous high-precision measurement and analysis of generic reference signals by using inexpensive commercial off-the-shelf software-defined radio hardware.
Beuster, N.   +4 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

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