Results 121 to 130 of about 4,130,659 (297)
Clinical Implementation of Precision Medicine: Current Challenges and Future Perspectives [PDF]
, 2016 Precision medicine has attracted tremendous global attentions in the past few years. A great deal of strikingly successful cases using targeted therapies for cancers and other critical human diseases have been reported and proved the effectiveness of ...
Wang, MD, Zhiqiang +5 more
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Transcriptomic data integration for precision medicine in leukemia [PDF]
, 2019 This thesis is comprised of three studies demonstrating the application of different statistical and bioinformatic approaches to address distinct challenges of implementing precision medicine strategies for hematological malignancies.
Kumar, Ashwini
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Precision medicine: precision viticulture [PDF]
Bone Marrow Transplantation, 2022 openaire +2 more sources
Genomic medicine, precision medicine, and personalized medicine: A survey of Turkish physicians’ perspectives on new paradigms in medicine [PDF]
Advances in medicine and new approaches are transforming health services. How these new approaches affect clinicians' decision-making is still unclear. This research aimed to evaluate the reflections of the concepts of personalized, genomic and precision
Gamsızkan, Zerrin, Sungur, Mehmet Ali
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The fuzzy world of precision medicine: deliberations of a precision medicine tumor board
, 2017 Aim: To understand how a cancer precision medicine tumor board (CPM-TB) made choices about return of results. Materials & methods: Observed CPM-TB deliberations and completed in-depth interviews with committee members.
Gray, Stacy W +10 more
core +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Moonshot for Precision Medicine [PDF]
Journal of Immunotherapy and Precision Oncology, 2019 Jordi Rodon
doaj +1 more source