Results 101 to 110 of about 648,115 (257)

Clinical Implementation of Precision Medicine: Current Challenges and Future Perspectives

, 2016
Precision medicine has attracted tremendous global attentions in the past few years. A great deal of strikingly successful cases using targeted therapies for cancers and other critical human diseases have been reported and proved the effectiveness of ...
Wang, MD, Zhiqiang, Ding, MD, PhD, Yan, Zhao, MD, Dewei, Kong, MD, Xuejun, Wang, MD, Ruoyu, Liu, MD, Xiao   +5 more
core  

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Precision Medicine: What Challenges Are We Facing?

, 2016
Following the publication of the US National Research Council (NRC) report ‘‘Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Diseases” in 2011 [1], several nations have announced that their national ...
Zhang, Xuegong, Yun Liu, Jingfa Xiao, Ye, Kai, Yu J, Zhang, Zhang, Shuhua Xu, Xiaoyue Wang, Ge Gao, Chang, Suhua, Yu Xue, Xiao, Jingfa, Wang, Xiaoyue, Li, Jian, Yu, Jun, Kunlin Zhang, Jianmin Wu, Wu, Jianmin, Suhua Chang, Xuegong Zhang, Eric-Wubbo Lameijer, Xuerui Yang, Chunsheng Han, Zhao, Fangqing, Lameijer, Eric-Wubbo, Han, Chunsheng, Liu, Yun, Huang, Kun, Jun Yu, Jian Li, Yang, Xuerui, Fangqing Zhao, Gao, Ge, Xu, Shuhua, Ying, Xiaomin, Zhang Zhang, Xue, Yu, Zhang, Kunlin, Xiaomin Ying, Kun Huang, Kai Ye, Wei-Hua Chen, Chen, Wei-Hua   +42 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Precision Medicine: Maximising Treatment Benefit for Rheumatoid Arthritis Patients

, 2016
This educational symposium was opened by Prof Ernest Choy, who introduced the concept of precision medicine and highlighted the importance of integrating current research with clinical experience to guide treatment decisions.
Georg Schett, Ernest Choy, Cem Gabay, Eric Ruderman   +3 more
core  

Precision Medicine [PDF]

Einstein (São Paulo), 2017
openaire   +4 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source