Results 81 to 90 of about 5,006,360 (256)
Transdisciplinary Perspectives on Precision Medicine
Health Equity, 2021 Purpose: The Precision Medicine Health Disparities Collaborative fosters collaboration between researchers with diverse backgrounds in precision medicine and health disparities research, to include training at the interface between genomics and health ...
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The Kidney Precision Medicine Project and Single-Cell Biology of the Injured Proximal Tubule
Single-cell RNA sequencing (scRNA-seq) has led to major advances in our understanding of proximal tubule subtypes in health and disease. The proximal tubule serves essential functions in overall homeostasis, but pathologic or physiological perturbations ...
Eadon, Michael T. +3 more
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Precision Medicine in Lifestyle Medicine: The Way of the Future? [PDF]
, 2020 Precision medicine has captured the imagination of the medical community with visions of therapies precisely targeted to the specific individual’s genetic, biological, social, and environmental profile.
Kross, Andrea R +5 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
The Third Pillar of Precision Medicine — Precision Delivery
MedCommPrecision Medicine is thought of as having two main pillars: Precision Diagnosis and Precision Therapy. However, for Precision Medicine to reach its full potential, a third pillar is needed that we propose to call Precision Delivery.
Avnesh S. Thakor
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Precision Medicine and Precision Nursing: The Era of Biomarkers and Precision Health
International Journal of General Medicine, 2020 Nicola Ielapi,1,2,* Michele Andreucci,3,* Noemi Licastro,1,4 Teresa Faga,3 Raffaele Grande,5 Gianluca Buffone,6 Sabrina Mellace,7 Paolo Sapienza,5 Raffaele Serra1,4 1Interuniversity Center of Phlebolymphology (CIFL), International Research and ...
Ielapi N +8 more
doaj
A Study on Personal Information Issues and Policy Direction toward Precision Medicine
, 2017 This article aims to analyze the issues that may arise from the handling of personal information in precision medicine research and to suggest policy directions for precision medicine in Korea.
김현창, 김소윤
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