Results 61 to 70 of about 1,197,472 (281)
Precision Medicine for Lysosomal Disorders
Biomolecules, 2020 Precision medicine (PM) is an emerging approach for disease treatment and prevention that accounts for the individual variability in the genes, environment, and lifestyle of each person. Lysosomal diseases (LDs) are a group of genetic metabolic disorders
Filippo Pinto e Vairo +6 more
doaj +1 more source
Precision medicine in mood disorders
PCN Reports, 2022 The choice of the most appropriate psychoactive medication for each of our patients is always a challenge. We can use more than 100 psychoactive drugs in the treatment of mood disorders, which can be prescribed either alone or in combination.
Alessandro Serretti
doaj +1 more source
Advances in precision medicine: tailoring individualised therapies [PDF]
, 2017 The traditional bench-to-bedside pipeline involves using model systems and patient samples to provide insights into pathways deregulated in cancer.
Brown, James A.L. +3 more
core +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
iBiopsy® for Precision Medicine
European Medical Journal, 2018 A high-throughput artificial intelligence-powered image-based phenotyping platform, iBiopsy® (Median Technologies, Valbonne, France), which aims to improve precision medicine, is discussed in the presented review.
Johan Brag +4 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Precision Medicine in Cardiovascular Diseases
Cardiovascular Innovations and Applications, 2017 Since President Obama announced the Precision Medicine Initiative in the United States, more and more attention has been paid to precision medicine. However, clinicians have already used it to treat conditions such as cancer. Many cardiovascular diseases
Yan Liu, Jie Du
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The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Precision medicine at the crossroads
Human Genomics, 2017 There are bioethical, institutional, economic, legal, and cultural obstacles to creating the robust-precompetitive-data resource that will be required to advance the vision of “precision medicine,” the ability to use molecular data to target therapies to
Maynard V. Olson
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Introducing the microbiome into Precision Medicine [PDF]
, 2016 © The Author(s), 2016. This is the author's version of the work and is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Trends in Pharmacological Sciences 38 (2017): 81-91, doi:10.1016/j ...
Gilbert, Jack A., Kuntz, Thomas M.
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