Results 61 to 70 of about 5,006,360 (256)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Precision Medicine for Frontotemporal Dementia

Frontiers in Psychiatry, 2019
Frontotemporal dementia (FTD) is a common young-onset dementia presenting with heterogeneous and distinct syndromes. It is characterized by progressive deficits in behavior, language, and executive function.
Mu-N Liu, Mu-N Liu, Mu-N Liu, Chi-Ieong Lau, Chi-Ieong Lau, Chi-Ieong Lau, Ching-Po Lin, Ching-Po Lin, Ching-Po Lin   +8 more
doaj   +1 more source

iBiopsy® for Precision Medicine

European Medical Journal, 2018
A high-throughput artificial intelligence-powered image-based phenotyping platform, iBiopsy® (Median Technologies, Valbonne, France), which aims to improve precision medicine, is discussed in the presented review.
Johan Brag, Michaël Auffret, Corinne Ramos,, Yan Liu, Pierre Baudot   +4 more
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Patient perspectives and involvement in precision medicine research.

, 2021
The Kidney Precision Medicine Project will advance understanding of chronic kidney disease attributed to diabetes or hypertension and acute kidney injury through a protocol kidney biopsy used for deep phenotyping with state-of-the-art methodology.
Tuttle, Katherine, Stutzke, Christy, Knight, Richard, Kidney Precision Medicine Project,, Brown, Keith, Jefferson, Nichole, Hyashi, Lynda, Roberts, Glenda V, Bebiak, Jack, Campbell, Catherine, Dighe, Ashveena   +10 more
core  

primakov/precision-medicine-toolbox:

, 2022
The feedback for the 0.0 version was ...
Sergey Primakov, Lisa Lavrova
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Precision medicine at the crossroads

Human Genomics, 2017
There are bioethical, institutional, economic, legal, and cultural obstacles to creating the robust-precompetitive-data resource that will be required to advance the vision of “precision medicine,” the ability to use molecular data to target therapies to
Maynard V. Olson
doaj   +1 more source

Medical Micro/Nanorobots in Precision Medicine

Advanced Science, 2020
Advances in medical robots promise to improve modern medicine and the quality of life. Miniaturization of these robotic platforms has led to numerous applications that leverages precision medicine.
Fernando Soto, Jie Wang, Rajib Ahmed, Utkan Demirci   +3 more
doaj   +1 more source

Precision medicine in asthma: linking phenotypes to targeted treatments. [PDF]

, 2017
PURPOSE OF REVIEW: Asthma is a heterogeneous disease consisting of different phenotypes that are driven by different mechanistic pathways. The purpose of this review is to emphasize the important role of precision medicine in asthma management.
Chung, Kian F, Kian Fan Chung
core   +1 more source