Results 51 to 60 of about 4,130,659 (297)

FROM PERSONALIZED TO PRECISION MEDICINE

Рациональная фармакотерапия в кардиологии, 2017
The need to maintain a high quality of life against a backdrop of its inevitably increasing duration is one of the main problems of modern health care.
K. V. Raskina, E. Y. Martynova, A. V. Perfilyev, D. A. Sychev, G. N. Shuev, I. R. Fatkhutdinov, S. V. Musienko, D. A. Nikogosov, I. O. Zhegulina, L. G. Bavykina, Y. E. Poteshkin   +10 more
doaj   +1 more source

NLP for Precision Medicine [PDF]

Proceedings of ACL 2017, Tutorial Abstracts, 2017
We will introduce precision medicine and showcase the vast opportunities for NLP in this burgeoning field with great societal impact. We will review pressing NLP problems, state-of-the art methods, and important applications, as well as datasets, medical resources, and practical issues.
Hoifung Poon, Chris Quirk, Kristina Toutanova, Wen-tau Yih   +3 more
openaire   +2 more sources

Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential

, 2022
Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies.
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Lifestyle and Genetic Adaptations Study (OLaGA) Group   +1 more
core   +1 more source

Coronary Physiology: Delivering Precision Medicine?

Reviews in Cardiovascular Medicine, 2022
Coronary physiological assessment is now widely used to assess epicardial coronary lesions in cath lab. Based on clinical evidence, fractional flow reserve (FFR) is the gold standard method to select whether epicardial coronary lesions need ...
Laura Maitre-Ballesteros, Laurent Riou, Stephanie Marliere, Marjorie Canu, Estelle Vautrin, Nicola Piliero, Oliviez Ormezzano, Helene Bouvaist, Alexis Broisat, Catherine Ghezzi, Daniel Fagret, Gérald Vanzetto, Loïc Djaïleb, Gilles Barone-Rochette   +13 more
doaj   +1 more source

Precision medicine in cholangiocarcinoma [PDF]

Translational Gastroenterology and Hepatology, 2018
Cholangiocarcinoma is one of the epithelial cancers with the poorest prognosis and the narrowest therapeutic choice in humans. Compared with other cancer types, cholangiocarcinoma has been often neglected by oncology and liver research studies, thereby leaving many issues unsolved. Apart from the early and marked aggressiveness, one of the main reasons
PELLINO, ANTONIO, Loupakis, Fotios, Cadamuro, Massimiliano, Dadduzio, Vincenzo, Fassan, Matteo, Guido, Maria, Cillo, Umberto, Indraccolo, Stefano, Fabris, Luca   +8 more
openaire   +4 more sources

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Engineering Precision Medicine [PDF]

Advanced Science, 2018
AbstractAdvances in genomic sequencing and bioinformatics have led to the prospect of precision medicine where therapeutics can be advised by the genetic background of individuals. For example, mapping cancer genomics has revealed numerous genes that affect the therapeutic outcome of a drug.
Wujin Sun, Junmin Lee, Shiming Zhang, Cole Benyshek, Mehmet R. Dokmeci, Ali Khademhosseini   +5 more
openaire   +2 more sources

Rationale and design of the Kidney Precision Medicine Project.

, 2021
Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous, and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a precision-medicine approach to prevention, diagnosis, and treatment.
Tuttle, Katherine, Kidney Precision Medicine Project,, El-Achkar, Tarek M, de Boer, Ian H., Troyanskaya, Olga G., Vazquez, Miguel A., Palevsky, Paul M, Gaut, Joseph P., Azeloglu, Evren U, Hodgin, Jeffrey B, Toto, Robert D., Eadon, Michael T, O\u27Toole, John F, Troyanskaya, Olga G, Mariani, Laura H., McClelland, Robyn L., Mooney, Sean D., Brown, Keith, Mariani, Laura H, Bomback, Andrew S, El-Achkar, Tarek M., Barasch, Jonathan M., Schaub, Jennifer A, Sharma, Kumar, Balis, Ulysses G. J., Barisoni, Laura, Waikar, Sushrut S., Lienczewski, Chrysta, Moledina, Dennis G, Alpers, Charles E, Jain, Sanjay, Knight, Richard, Balis, Ulysses G J, Steck, Becky, Dagher, Pierre C, O'Toole, John F, Blank, Kristina N, Laszik, Zoltan G., Alpers, Charles E., Azeloglu, Evren U., Himmelfarb, Jonathan, O'Toole, John F., McClelland, Robyn L, Iyengar, Ravi, Kellum, John A, Kellum, John A., Dighe, Ashveena L, de Boer, Ian H, Wilson, Francis Perry, Kidney Precision Medicine Project, Toto, Robert D, Hodgin, Jeffrey B., Moledina, Dennis G., Waikar, Sushrut S, Williams, Kayleen, Rosas, Sylvia E., Kiryluk, Krzysztof, Kretzler, Matthias, Palevsky, Paul M., Tuttle, Katherine R, Sedor, John R., Sedor, John R, Rosengart, Matthew R, Hacohen, Nir, Poggio, Emilio D, Schaub, Jennifer A., Eadon, Michael T., He, Yongqun, Barasch, Jonathan M, Menez, Steven, Mooney, Sean D, Dagher, Pierre C., Sarwal, Minnie M., Vazquez, Miguel A, Tuttle, Katherine R., Dighe, Ashveena L., Rosengart, Matthew R., Parikh, Chirag R, Sarwal, Minnie M, Blank, Kristina N., Zhang, Kun, Parikh, Chirag R., Bomback, Andrew S., Gaut, Joseph P, Laszik, Zoltan G, Rosas, Sylvia E, Poggio, Emilio D.   +86 more
core   +1 more source

A Situational Assessment of the Diagnostic Landscape and Organizational Readiness to Implement Next‐Generation Sequencing at Two Childhood Cancer Treatment Centers in Ghana

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Next‐generation sequencing (NGS) has emerged as a promising approach to improve diagnostic accuracy, but its feasibility in low‐ and middle‐income countries remains unknown. This study characterized the diagnostic landscape and assessed organizational readiness for NGS implementation at two childhood cancer treatment centers in Accra ...
Melissa Carvalho, Emmanuella Amoako, Nihad Salifu, Lily Gloria Tagoe, Yaw Bediako, Michelle Hermiston, Catherine Segbefia   +6 more
wiley   +1 more source

Precision medicine and lymphoma [PDF]

Current Opinion in Hematology, 2018
Purpose of review The treatment of the germinal center lymphomas, diffuse large B cell (DLBCL) and follicular lymphoma, has changed little beyond the introduction of immunochemotherapies. However, there exists a substantial group of patients within both diseases for which improvements in care will involve appropriate tailoring ...
Heward, JA, Kumar, EA, Korfi, K, Okosun, J, Fitzgibbon, J   +4 more
openaire   +3 more sources