Results 71 to 80 of about 648,115 (257)

Patients' perspectives related to ethical issues and risks in precision medicine : a systematic review

, 2023
Background: Precision medicine is growing due to technological advancements including next generation sequencing techniques and artificial intelligence.
Chatzittofis, Andreas, Ahmed, Lawko,, Ahmed, Lawko, Chatzittofis, Andreas,, Constantinidou, Anastasia, Constantinidou, Anastasia,   +5 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cancer genomics, biomarkers and precision medicine

This chapter emphasizes the role of genomics in global cancer control, detailing advancements in genome sequencing technologies that have enabled the identification of genetic alterations driving over 200 types of cancer.
Oldfield, LE, Pugh, TJ
core   +1 more source

Tri©DB: an integrated platform of knowledgebase and reporting system for cancer precision medicine

, 2023
Background With the development of cancer precision medicine, a huge amount of high-dimensional cancer information has rapidly accumulated regarding gene alterations, diseases, therapeutic interventions and various annotations.
Jiang, W, Weicai Ye, Lin, QT, Shihui Yang, Tan, X, Ye, W, Huang, X, Bao, YJ, Xiaoming Tan, Yuedong Yang, Yang, Y, Qi Zhou, Yang, S, Yun-Juan Bao, Yao Yao, Wei Jiang, Zhou, Q, Qiu-Tong Lin, Wang, PY, Yao, Y, Xun Huang, Peng-Ying Wang   +21 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Anticancer biomaterials: A special design for precision medicine

Despite prominent progress in cancer detection and therapy, critical challenges still remain and need to be addressed. In this sense, several innovative biomaterials have been designed and produced using different types of biocompatible materials like ...
Azari Z., Nazarnezhad S., Gorgani S., Baino F., Hosseini S. A.   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Genomic medicine, precision medicine, and personalized medicine: A survey of Turkish physicians’ perspectives on new paradigms in medicine [PDF]

Advances in medicine and new approaches are transforming health services. How these new approaches affect clinicians' decision-making is still unclear. This research aimed to evaluate the reflections of the concepts of personalized, genomic and precision
Gamsızkan, Zerrin, Sungur, Mehmet Ali
core   +1 more source