Results 241 to 250 of about 4,218,282 (383)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Precision medicine in colorectal cancer

The Saudi Journal of Gastroenterology, 2019
Mohammad Azhar Aziz
doaj   +1 more source

The promises of precision medicine - voices from the Nordics. [PDF]

Acta Oncol
Nilbert M.
europepmc   +1 more source

Treatment options for infections caused by carbapenem-resistantEnterobacteriaceae: can we apply “precision medicine” to antimicrobial chemotherapy? [PDF]

, 2016
Federico Pérez, Nadim G. El Chakhtoura, Krisztina M. Papp‐Wallace, Brigid Wilson, Robert A. Bonomo   +4 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

IgA Vasculitis Across the Ages: Is It Time for a Precision Medicine Approach? [PDF]

ACR Open Rheumatol
Gage A, Pepper RJ, Marro J, Salama AD, Oni L.   +4 more
europepmc   +1 more source

OpenGeneMed: a portable, flexible and customizable informatics hub for the coordination of next-generation sequencing studies in support of precision medicine trials [PDF]

, 2016
Alida Palmisano, Yingdong Zhao, Ming-Chung Li, Eric C. Polley, Richard Simon   +4 more
openalex   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Precision Medicine vs Medical Judgement

Cardiovascular Innovations and Applications, 2017
C. Richard Conti
doaj   +1 more source

The Qatar genome: a population-specific tool for precision medicine in the Middle East [PDF]

, 2016
Khalid A. Fakhro, Michelle R. Staudt, Monica D. Ramstetter, Amal Robay, Joel A. Malek, Ramin Badii, Ajayeb Al‐Nabet Al‐Marri, Charbel Abi Khalil, Alya Al-Shakaki, Omar Chidiac, Dora J. Stadler, Mahmoud Zirie, Amin Jayyousi, Jacqueline Salit, Jason G. Mezey, Ronald G. Crystal, Juan L. Rodríguez-Flores   +16 more
openalex   +1 more source