Results 11 to 20 of about 164,371 (301)

Applying Precision Oncology Principles in Radiation Oncology

JCO Precision Oncology, 2018
Radiation therapy is a critical component in the curative management of many solid tumor types, and advances in radiation delivery techniques during the past decade have led to improved disease control and quality of life for patients. During the same period, remarkable advances have also been made in understanding the genomic landscape of tumors ...
Sophia C, Kamran, Kent W, Mouw
openaire   +4 more sources

An Approach to Solving the Complex Clinicogenomic Data Landscape in Precision Oncology: Learnings From the Design of WAYFIND-R, a Global Precision Oncology Registry [PDF]

, 2022
Precision oncology, where patients are given therapies based on their genomic profile and disease trajectory, is rapidly evolving to become a pivotal part of cancer management, supported by regulatory approvals of biomarker-matched targeted therapies and
Dienstmann, Rodrigo, Le Tourneau, Christophe, Hackshaw, Allan, von Meyenn, Martina, Jean-Yves Blay, Jan Geissler, Blay, Jean-Yves, Do, Thy, Martina von Meyenn, Thy Do, Nabholz, Christoph, Christoph Nabholz, Rodrigo Dienstmann, Allan Hackshaw, Perret, Camille, Camille Perret, Geissler, Jan, Christophe Le Tourneau   +17 more
core   +1 more source

Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM [PDF]

, 2022
The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a two-year pilot study implementing ex vivo drug sensitivity profiling (DSP) using a library of 75 ...
Sonja Herter, Gerloff, Xenia F., Tim Holland-Letz, Pietiäinen, Vilja, Oppermann, Sina, Aileen Friedenauer, Christopher Previti, Reuss, David, Holland-Letz, Tim, Nora Jamaladdin, Nathrath, Michaela, Caroline Hutter, Witt, Olaf, Berker, Yannick, Gnanaprakash Balasubramanian, Jaeger, Natalie, Monika Sparber-Sauer, David Reuss, Michaela Nathrath, Blattner-Johnson, Mirjam, Johannes Gojo, Olaf Witt, Jamaladdin, Nora, Pfister, Stefan M., Kopp-Schneider, Annette, Kallioniemi, Olli, Sill, Martin, Gojo, Johannes, Milde, Till, Petra Fiesel, Dirksen, Uta, Heike Peterziel, Previti, Christopher, Stephan Tippelt, Tippelt, Stephan, Laura Turunen, Vilja Pietiäinen, Matthias Schlesner, Jani Saarela, Hutter, Caroline, van Tilburg, Cornelis M., Sehested, Astrid, Astrid Sehested, Annette Kopp-Schneider, Kathrin Schramm, Jones, David T.W., Oehme, Ina, Norbert Graf, Xenia F. Gerloff, Jäger, Natalie, Stefan M. Pfister, Barbara C. Jones, ElHarouni, Dina, Ina Oehme, Nicolas U. Gerber, Olli Kallioniemi, Gerber, Nicolas U., Balasubramanian, Gnanaprakash, Ingrid Øra, ora, Ingrid, Turunen, Laura, Lohi, Olli, Lena Weiser, Schramm, Kathrin, Westermann, Frank, Weiser, Lena, Cornelis M. van Tilburg, Graf, Norbert, Olli Lohi, Antonis Kattamis, Yannick Berker, David T. W. Jones, Schlesner, Matthias, Bram de Wilde, Øra, Ingrid, Kattamis, Antonis, Jones, David T. W., Christof M. Kramm, Sina Oppermann, Fiesel, Petra, Sparber-Sauer, Monika, Herter, Sonja, Jones, Barbara C., de Wilde, Bram, Dina ElHarouni, Mirjam Blattner-Johnson, Peterziel, Heike, Till Milde, Kramm, Christof M., Friedenauer, Aileen, Natalie Jäger, Martin Sill, Uta Dirksen, Frank Westermann, Saarela, Jani   +94 more
core   +1 more source

Clonotyping for precision oncology [PDF]

Drug Discovery Today, 2015
Advances in identifying subpopulations of cancer cells and reconstructing the clonal evolution of tumors greatly enhance our understanding of the molecular events within a patient and their context relative to one another. In the rapidly unfolding era of personalized medicine, the ability to monitor clonal dynamics throughout patient care has ...
Ha X, Dang, Christopher A, Maher
openaire   +2 more sources

Precision oncology for RET-related tumors

Frontiers in Oncology, 2022
Aberrant activation of the RET proto-oncogene is implicated in a plethora of cancers. RET gain-of-function point mutations are driver events in multiple endocrine neoplasia 2 (MEN2) syndrome and in sporadic medullary thyroid cancer, while RET ...
Antonella Verrienti, Giorgio Grani, Marialuisa Sponziello, Valeria Pecce, Giuseppe Damante, Cosimo Durante, Diego Russo, Sebastiano Filetti   +7 more
doaj   +1 more source

Evolving Landscape of Molecular Prescreening Strategies for Oncology Early Clinical Trials [PDF]

, 2020
Oncologia de precisió; Assaigs clínics; Preselecció molecularOncología de precisión; Ensayos clínicos; Preselección molecularPrecision oncology; Clinical Trials; Molecular prescreeningMost academic precision oncology programs have been designed to ...
Grazia LoGiacco, Deborah, González-Zorelle, Jenifer, Aguilar, Susana, Ogbah, Zighereda, Oaknin Benzaquen, Ana Mazaltob, Antunes de Melo Oliveira, Ana Mafalda, Fasani, Roberta, Ruiz Pace, Fiorella, Sala De Vedruna, Gemma, Ramos Masdeu, Laia, Dienstmann, Rodrigo, Martinez, Paola, Braña Garcia, Irene, Balmaña Gelpí, Judith, Elez Fernandez, Mª Elena, Felip Font, Enriqueta, Tabernero Caturla, Josep, Nuciforo, Paolo Giovanni, Vivancos Prellezo, Ana, Alsina Maqueda, Maria, Garralda Cabanas, Elena, Viaplana Donato, Cristina, Rodon Ahnert, Jordi, Mancuso, Francesco Mattia, Macarulla Mercadé, Teresa, Jiménez Flores, José Antonio, Carles Galceran, Joan, Saura Manich, Cristina   +27 more
core   +1 more source

Precision Oncology and Cancer Biomarkers [PDF]

, 2022
This open access book reflects on matters of social and ethical concern raised in the daily practices of those working in and around precision oncology. Each chapter addresses the experiences, concerns and issues at stake for people who work in settings ...

core   +4 more sources

Precision Medicine in Lung Cancer

European Medical Journal Oncology, 2020
Lung cancer has a devastating global impact, with diagnosis of more than 2 million new cases annually, and poor long-term survival. Recently, the landscape of lung cancer diagnosis, staging, and treatment has changed profoundly, with further developments
Esha Joshi
doaj   +1 more source

Precision Cardio-Oncology [PDF]

Journal of Nuclear Medicine, 2019
Modern oncologic therapies and care have resulted in a growing population of cancer survivors with comorbid, chronic health conditions. As an example, many survivors have an increased risk of cardiovascular complications secondary to cardiotoxic systemic and radiation therapies.
Alexandra D, Dreyfuss, Paco E, Bravo, Constantinos, Koumenis, Bonnie, Ky   +3 more
openaire   +2 more sources

Epigenetics and Precision Oncology [PDF]

The Cancer Journal, 2017
Abstract Epigenetic alterations such as DNA methylation defects and aberrant covalent histone modifications occur within all cancers and are selected for throughout the natural history of tumor formation, with changes being detectable in early onset, progression, and ultimately recurrence and metastasis.
Rachael J, Werner, Andrew D, Kelly, Jean-Pierre J, Issa   +2 more
openaire   +2 more sources