Results 21 to 30 of about 164,371 (301)
Consensus Statements on Precision Oncology in the China Greater Bay Area
, 2023 Background: Next-generation sequencing comprehensive genomic panels (NGS CGPs) have enabled the delivery of tailor-made therapeutic approaches to improve survival outcomes in patients with cancer.
Hui, CV +30 more
core +1 more source
Landscape of KRASG12C, Associated Genomic Alterations, and Interrelation With Immuno-Oncology Biomarkers in KRAS-Mutated Cancers [PDF]
, 2022 Genomic alterations; Mutated cancers; Immuno-oncologyAlteraciones genómicas; Cánceres mutados; Inmuno-oncologíaAlteracions genòmiques; Càncers mutats; Immuno-oncologiaPURPOSE Promising single-agent activity from sotorasib and adagrasib in KRASG12C ...
El-Refai, Sherif M. +6 more
core +1 more source
Red shell‐ high risk normal tissue in stereotactic radiosurgery
Precision Radiation Oncology, 2023 Due to the ablative nature of high prescription in Stereotactic Radiosurgery or stereotactic body radiation therapy (SRS/SBRT), the normal tissue surrounding the CTV receives the dose higher than tissue's dose constraint.
Jun Yang +6 more
doaj +1 more source
Precision Oncology in Gastrointestinal Stromal Tumors
Current Oncology, 2023 GIST (gastrointestinal stromal tumors) represent 20% of sarcomatous tumors and 1–2% of primary gastrointestinal cancers. They have an excellent prognosis when localized and resectable, though their prognosis is poor in the metastatic setting, with ...
Hiba Mechahougui +2 more
doaj +1 more source
Precision Oncology in Gastro-Esophageal Adenocarcinoma
healthbook TIMES. Oncology Hematology, 2020 Gastro-esophageal adenocarcinomas (GEA) are a leading cause of cancer mortality, with limited therapeutic strategies available. With the advent of next-generation sequencing (NGS) and novel technologies, our understanding of its pathogenesis and ...
Marco Cefalì +2 more
doaj +1 more source
Integrating proteomics into precision oncology [PDF]
International Journal of Cancer, 2020 AbstractDNA sequencing and RNA sequencing are increasingly applied in precision oncology, where molecular tumor boards evaluate the actionability of genetic events in individual tumors to guide targeted treatment. To work toward an additional level of patient characterization, we assessed the abundance and activity of 27 proteins in 134 patients whose ...
Leonie W. Wahjudi +20 more
openaire +2 more sources
The road to precision oncology [PDF]
Nature Genetics, 2017 The ultimate goal of precision medicine is to use population-based molecular, clinical and other data to make individually tailored clinical decisions for patients, although the path to achieving this goal is not entirely clear. A new study shows how knowledge banks of patient data can be used to make individual treatment decisions in acute myeloid ...
openaire +2 more sources
Precision Genomic Practice in Oncology: Pharmacist Role and Experience in an Ambulatory Care Clinic
Pharmacy, 2020 Recent advancements in molecular testing, the availability of cost-effective technology, and novel approaches to clinical trial design have facilitated the implementation of tumor genome sequencing into standard of care oncology practices. Current models
Farah Raheem +3 more
doaj +1 more source
Actionability and precision oncology
Oncoscience, 2015 Cancer is driven by molecular aberrations that allow oncogenic cells to thrive by growing and eventually metastasizing, and/or by alterations in the tumor or host that are permissive for immune evasion. The development and availability of clinical-grade molecular diagnostic tests that interrogate the genomic portfolio of each patient's tumor, together ...
Schwaederle, Maria, Kurzrock, Razelle
openaire +4 more sources
Genomics and the History of Precision Oncology [PDF]
Surgical Oncology Clinics of North America, 2020 Progress toward the implementation of a molecular characterization paradigm in cancer drug development over the past 20 years has markedly enhanced our capability to select patients who are more likely to benefit from cancer therapy. Improvements in genomic and related diagnostic testing platforms have permitted evaluation of the efficacy of treatment ...
Deborah B, Doroshow, James H, Doroshow
openaire +2 more sources