Results 261 to 270 of about 789,487 (311)
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Journal of Aerosol Medicine and Pulmonary Drug Delivery
Several inhaled proteins and peptides have been developed to treat indications in the respiratory tract or systemically with varying degrees of success. This section will summarize the preclinical and clinical studies for inhaled Pulmozyme® (recombinant human deoxyribonuclease, rhDNase), insulin, human growth hormone (hGH), cyclosporine, alpha-1 ...
Ronald K, Wolff, James D, Blanchard
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Several inhaled proteins and peptides have been developed to treat indications in the respiratory tract or systemically with varying degrees of success. This section will summarize the preclinical and clinical studies for inhaled Pulmozyme® (recombinant human deoxyribonuclease, rhDNase), insulin, human growth hormone (hGH), cyclosporine, alpha-1 ...
Ronald K, Wolff, James D, Blanchard
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Preclinical Overview of Brinzolamide
Survey of Ophthalmology, 2000The development of topically active carbonic anhydrase inhibitors (CAIs) is a significant recent achievement in glaucoma medical treatment. Brinzolamide, the newest topical CAI, exhibits selectivity, high affinity, and potent inhibitory activity for the carbonic anhydrase type II isozyme (CA-II), which is involved in aqueous humor secretion.
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2002
Man is unable to actively eliminate iron from the body, once it has been acquired. Toxic and eventually lethal levels of iron accumulate as a result of repeated transfusions, e.g. in s-thalassemia major, or due to excessive dietary iron uptake in anemias and hereditary hemochromatosis.
Hanspeter, Nick +9 more
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Man is unable to actively eliminate iron from the body, once it has been acquired. Toxic and eventually lethal levels of iron accumulate as a result of repeated transfusions, e.g. in s-thalassemia major, or due to excessive dietary iron uptake in anemias and hereditary hemochromatosis.
Hanspeter, Nick +9 more
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Preclinical evaluation of brimonidine
Survey of Ophthalmology, 1996Preclinical studies of brimonidine show that it is a potent alpha 2-adrenoceptor agonist that is 1000-fold more selective for the alpha 2-vs. the alpha 1-adrenoceptor, and is 7-12-fold more alpha 2-selective than clonidine and 23- to 32-fold more alpha 2-selective than apraclonidine (p-aminoclonidine).
J, Burke, M, Schwartz
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Toxicokinetics in preclinical evaluation
Drug Discovery Today, 2003Toxicokinetic evaluation is both a regulatory and scientific requirement in the drug development process. However, as a fairly new term, its use within the industry is still confused. Toxicokinetics is the generation of kinetic data to assess systemic exposure, either as an integral component of preclinical toxicity studies, or in specially designed ...
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Preclinical Pharmacology of Metrifonate
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1998Alzheimer's disease is a chronic neurodegenerative disorder that is characterized by memory impairment, cognitive dysfunction, behavioral disturbances, and deficits in activities of daily living. A consistent observation in these patients is that cholinergic neurons are affected and deteriorate over time, leading to decreased levels of acetylcholine ...
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Preclinical abortions and endometriosis
Fertility and Sterility, 1988A single human chorionic gonadotropin determination was performed in 786 infertile women during the late luteal phase to determine the frequencies of preclinical abortions and whether the frequency was increased in women with endometriosis. Thirty-seven pregnancies (4.7% of cycles) were identified, of which six were classified as preclinical abortions (
D E, Pittaway, C P, Ellington, M, Klimek
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Preclinical industrial research
Trends in Pharmacological Sciences, 1996From very early on in my career as a pharmacologist, I knew in my heart that I would do research in the pharmaceutical industy. This was not based on economical grounds, but was based on the fact that I am committed to participate in the discovery and development of drugs that will allievate human suffering.
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2013
Before pharmaceutical products are evaluated in humans, it is essential that they undergo a rigorous safety assessment using in vitro models and studies in preclinical species. Once products progress into the clinic, additional preclinical studies are needed to support further clinical testing.
Jonathon D S, Holt, Jeremy P, Nuttall
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Before pharmaceutical products are evaluated in humans, it is essential that they undergo a rigorous safety assessment using in vitro models and studies in preclinical species. Once products progress into the clinic, additional preclinical studies are needed to support further clinical testing.
Jonathon D S, Holt, Jeremy P, Nuttall
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Preclinical Models of Meningioma
2023The management of clinically aggressive meningiomas remains challenging due to limited treatment options aside from surgical removal and radiotherapy. High recurrence rates and lack of effective systemic therapies contribute to the unfavorable prognosis of these patients.
Gerhard, Jungwirth +3 more
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