Results 201 to 210 of about 303,204 (352)

480 Nonlinear Optics Histopathology: A New Paradigm for Preclinical Drug Evaluation [PDF]

Kayvan F. Tehrani, Aneesh Alex, Adrian R. Liversage, Terrence T. Roh, Prabhakar Pandian, Carla F. Newman, Reid Groseclose   +6 more
openalex   +1 more source

Ultrasound‐Triggered Gelation for Restoring Biomechanical Properties of Degenerated Functional Spinal Units

Advanced Healthcare Materials, EarlyView.
This study introduces an innovative approach to treating intervertebral disc degeneration using ultrasound‐triggered in situ hydrogel formation. Proof‐of‐concept experiments using optimized biomaterial and ultrasound parameters demonstrate partial restoration of biomechanical function and successful integration into degenerated disc tissue, offering a ...
Veerle A. Brans, Anna P. Constantinou, Matthew J. Kibble, Valeria Nele, Daniel Reumann, Luca Bau, Sebastien J. P. Callens, James P. K. Armstrong, Nicolas Newell, Constantin C. Coussios, Molly M. Stevens, Michael D. Gray   +11 more
wiley   +1 more source

Integrating New Approach Methodologies (NAMs) into Preclinical Regulatory Evaluation of Oncology Drugs. [PDF]

Biomimetics (Basel)
Mirlohi MS, Yousefi T, Aref AR, Seyfoori A.   +3 more
europepmc   +1 more source

Supplementary Figures S11-18 from Design and Preclinical Evaluation of a Novel B7-H4–Directed Antibody–Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305

Krista Kinneer, Philipp Wortmann, Zachary A. Cooper, Niall J. Dickinson, Luke A. Masterson, Thais Cailleau, Ian Hutchinson, Balakumar Vijayakrishnan, Mary McFarlane, Kathryn Ball, Michael Davies, Arthur Lewis, Yue Huang, Anton I. Rosenbaum, Jiaqi Yuan, Jon Chesebrough, Judith Anderton, Noel R. Monks, Steven Novick, Jixin Wang, Nazzareno Dimasi, R. James Christie, Darrin Sabol, Frances Anne Tosto, Yann Wallez, Elisabetta Leo, Mark R. Albertella, Anna D. Staniszewska, David A. Tice, Philip W. Howard, Nadia Luheshi, Puja Sapra   +31 more
openalex   +1 more source

Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation [PDF]

, 2013
Chris J. Scotton, Brian Hayes, Robert Alexander, Arnab Datta, Ellen Forty, Paul F. Mercer, Andy Blanchard, Rachel C. Chambers   +7 more
openalex   +1 more source

Preclinical evaluation of ePSMA-DM1: a PSMA-targeting theranostic small molecule drug conjugate

Nuclear Medicine and Biology, 2023
Seimbille, Yann, Murce, Erika, Spaan, Evelien, Beekman, Savanne, Handula, Maryana, de Ridder, Corrina, Stuurman, Debra   +6 more
openaire   +1 more source

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source

Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Hybrid wrinkled topographies coordinate immune, tissue, and bacterial interactions. The surfaces promote osteointegration, tune macrophage polarization, and inhibit biofilm formation, highlighting a multifunctional strategy for next‐generation implant design.
Mohammad Asadi Tokmedash, Jacob Robins, J. Scott VanEpps, Minji Kim, Jouha Min   +4 more
wiley   +1 more source

Gross tumor assessment is not a reliable measure of the efficacy of chemo-preventive agents for breast cancer in preclinical mouse models. [PDF]

Sci Rep
Bhardwaj A, Koh A, Embury MD, Sandhu J, Rojo RD, Albarracin CT, Bedrosian I.   +6 more
europepmc   +1 more source

First-generation and preclinical evaluation of an EphA5-targeted antibody-drug conjugate in solid tumors

Fernanda I. Staquicini, Fenny H. F. Tang, Vanessa de Oliveira, Sun Young Kim, E. Chen, Christopher Markosian, Daniela I. Staquicini, Yongjian Wu, J. Kellogg Parsons, Kirstin F. Barnhart, Stephen C. Alley, Isan Chen, Wadih Arap, Renata Pasqualini   +13 more
openalex   +1 more source