Results 221 to 230 of about 192,321 (310)

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

Repurposed Medicines for Viruses With Epidemic or Pandemic Potential: A Horizon Scan. [PDF]

Pharmacol Res Perspect
Akinbolade S, Potter R, Inskip A, Nesworthy J, Brock K, Norman G.   +5 more
europepmc   +1 more source

An Imaging‐Guided, Patient‐Specific Guiding Aid (RWNGuide) for Safe and Reproducible Inner Ear Drug Delivery

Advanced Materials Technologies, EarlyView.
A patient‐specific, imaging‐guided aid enables precise and reproducible drug delivery to the inner ear. By guiding therapeutic agents directly to the round window niche, this approach reduces variability in drug localization, improves delivery safety, and addresses a critical bottleneck in inner ear therapy, offering a scalable strategy for precision ...
Yanjing Luo, Shanshan Jiang, Yimian Luo, Adele Moatti, Farnaz Matin‐Mann   +4 more
wiley   +1 more source

Therapeutic Targets, Pharmacological Mechanisms, and Delivery Strategies for Diabetic Peripheral Neuropathy. [PDF]

Drug Des Devel Ther
Wang F, Shen C, Guo W, Wang J, Xie J, Shen G, Lin Y.   +6 more
europepmc   +1 more source

Microneedles Mediated Delivery of Nanodiamonds for Quantum Sensing of Free Radicals in Skin Tissue

Advanced Materials Technologies, EarlyView.
Fluorescent nanodiamonds are nanoscale sensors capable of monitoring cellular stress responses. However, to function effectively, they must be delivered into cells or tissues. Here, we demonstrate their application in the skin by developing a dissolvable microneedle platform that dissolves after skin insertion, enabling the delivery of nanodiamonds ...
Siyu Fan, Maria Carmona Lobita, Thea Vedelaar, Yue Zhang, Claudia Reyes‐San‐Martin, Tomás Bauleth‐Ramos, Gésinda Geertsema‐Doornbusch, Han Gao, Mohammad‐Ali Shahbazi, Hélder A. Santos, Romana Schirhagl   +10 more
wiley   +1 more source

Intelligent therapeutic robotic-assisted surgery as the next frontier of precision oncology. [PDF]

Front Oncol
Satyam SM, Wali AF, El-Tanani M, Sarfraz A, Khalil I, Alghoul WI, Bhat AA, Mansor I, Alhammadi MA, Al-Shammari WBJ, Nasser RAS, Menon A, Alahmad OM.   +12 more
europepmc   +1 more source

Extrusion Bioprinting for Wound Healing: Innovations in Functionalized Bioinks and Bioprinting Technology

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting (EBB) has emerged as a versatile biofabrication platform capable of precisely depositing bioinks composed of biomaterials, cells, and bioactive agents to generate patient‐specific, biomimetic skin constructs. This paper presents a state‐of‐the‐art and forward‐looking overview of EBB for wound healing, encompassing printing ...
Hien‐Phuong Le, Anh Tuan Trong Tran, Ammara Waheed, Tran Thanh Tung, Dusan Losic   +4 more
wiley   +1 more source

Therapeutic Targets for Pediatric Pulmonary Vein Stenosis: Insights from Animal Models. [PDF]

Children (Basel)
She S, Li D, Sun Q, Ye L.
europepmc   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Current Advances in Preclinical Patient-Derived Cultivation Models for Individualized Drug Response Prediction in Pancreatic Cancer. [PDF]

Oncol Res
Heckelmann B, Duhn J, Braun R.
europepmc   +1 more source