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Anti-cancer drug sensitivity testing and preclinical evaluation of the anti-cancer potential of WEE1 inhibitor in triple-negative breast cancer patient-derived organoids and xenograft models

open access: gold
S. Ryu   +13 more
openalex   +1 more source

Integrative genomic and bioinformatic prioritization of drug repurposing candidates for prostate cancer. [PDF]

open access: yesBMC Pharmacol Toxicol
Irham LM   +12 more
europepmc   +1 more source
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Technological Advances in Preclinical Drug Evaluation: the Role of -Omics Methods.

Current Medicinal Chemistry, 2020
Preclinical drug development is an essential step in the drug development process where evaluation of new chemical entities occurs. In particular, preclinical drug development phases include deep analysis of drug candidates' interactions with ...
S. K. Pavelić   +4 more
semanticscholar   +5 more sources

Orthotopic models of cancer for preclinical drug evaluation: advantages and disadvantages.

European Journal of Cancer, 2004
Considering the enormous effort that has taken place over the years to discover new chemotherapeutic drugs for treating the common cancers, the conventional murine and xenograft test systems used to test efficacy for drug development have identified only a limited number of useful agents that are active clinically at well tolerated doses.
M. Bibby
semanticscholar   +4 more sources

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