T-type Ca2+ Channels: T for Targetable [PDF]
, 2018 In the last decade TTCC have been unveiled as key regulators of cancer cells biology and thus have been proposed as chemotherapeutic targets. Indeed in vitro and in vivo studies indicate that TTCC pharmacological blockers have a negative impact on the ...
Cantí Nicolás, Carles +5 more
core +2 more sources
EXPERT EVALUATION OF PRECLINICAL STUDIES OF PRIMARY AND SECONDARY PHARMACODYNAMICS OF MEDICINES
Регуляторные исследования и экспертиза лекарственных средств, 2018 The article dwells upon the results of comparative analysis of the Russian national requirements and EAEU regulations dealing with evaluation of preclinical pharmacological studies.
G. N. Engalycheva +3 more
doaj +1 more source
Preclinical species gene expression database: Development and meta-analysis
Frontiers in Genetics, 2023 The evaluation of toxicity in preclinical species is important for identifying potential safety liabilities of experimental medicines. Toxicology studies provide translational insight into potential adverse clinical findings, but data interpretation may ...
Caitlin Krause +10 more
doaj +1 more source
Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies [PDF]
, 2019 In cancer research, it remains challenging to functionally validate putative novel oncogenic drivers and to establish relevant preclinical models for evaluation of novel therapeutic strategies.
Berx, Geert +16 more
core +2 more sources
Statistical Learning in Preclinical Drug Proarrhythmic Assessment [PDF]
arXiv, 2021 Torsades de pointes (TdP) is an irregular heart rhythm characterized by faster beat rates and potentially could lead to sudden cardiac death. Much effort has been invested in understanding the drug-induced TdP in preclinical studies. However, a comprehensive statistical learning framework that can accurately predict the drug-induced TdP risk from ...
arxiv
Neuroprotective efficacy of P7C3 compounds in primate hippocampus. [PDF]
, 2018 There is a critical need for translating basic science discoveries into new therapeutics for patients suffering from difficult to treat neuropsychiatric and neurodegenerative conditions.
Bauman, Melissa D +8 more
core +2 more sources
Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes
Nature Communications, 2022 Nanoelectrodes for measuring intracellular action potentials suffer from issues with success rate, signal strength and fabrication. Here, the authors report on a scalable technique which creates robust nanocrown electrodes with high success rates by ...
Zeinab Jahed +16 more
doaj +1 more source
Application of Small Epigenetic Modulators in Pediatric Medulloblastoma [PDF]
, 2018 Medulloblastoma is one of the most frequent among pediatric brain tumors, and it has been classified in various subgroups. Some of them already benefit from quite good therapeutic options, whereas others urgently need novel therapeutic approaches ...
Annalisa Romanelli +8 more
core +2 more sources
A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses [PDF]
, 2016 Background. Glioblastoma (GBM) is the most common primary brain tumor, with dismal prognosis. The failure of drug–radiation combinations with promising preclinical data to translate into effective clinical treatments may relate to the use of simplified
Chalmers, Anthony +4 more
core +2 more sources
Ozone therapy improves early stages of osseointegration in ovariectomized rats [PDF]
Journal of Applied Oral ScienceObjective the aim of this study was to analyze the influence of ozone therapy (OZN) on peri-implant bone repair in critical bones by installing osseointegrated implants in the tibia of ovariectomized rats.
William Phillip Pereira da SILVA +8 more
doaj +1 more source