Results 31 to 40 of about 8,733,364 (311)

Comparative evaluation of recommendations for preclinical studies of transporter-mediated drug–drug interactions

Регуляторные исследования и экспертиза лекарственных средств, 2023
Scientific relevance. Sound recommendations for preclinical studies of transporter- mediated pharmacokinetic interactions of medicinal products can help increase the likelihood of identifying potentially nephrotoxic and hepatotoxic medicinal products at ...
V. A. Evteev, N. D. Bunyatyan, E. Yu. Demchenkova, A. B. Prokofiev   +3 more
doaj   +1 more source

Study on Research and Development Status and Application of 90Y Microspheres

Journal of Isotopes, 2022
With 90Y microspheres, radioactive microspheres are perfused to tumor feeding arteries through minimally invasive intervention, and then diffused and retained in small vessels of tumor terminals along with blood flow, so as to high selectively kill tumor
GAO Jie;LIU Xiaoming;ZHOU Wenhua;WANG Hongliang;ZHAO Xiaosheng;GE Qiang;LI Jianguo
doaj  

Computational Approaches in Preclinical Studies on Drug Discovery and Development

Frontiers in Chemistry, 2020
Because undesirable pharmacokinetics and toxicity are significant reasons for the failure of drug development in the costly late stage, it has been widely recognized that drug ADMET properties should be considered as early as possible to reduce failure ...
Fengxu Wu, Fengxu Wu, Yuquan Zhou, Yuquan Zhou, Langhui Li, Langhui Li, Xianhuan Shen, Xianhuan Shen, Ganying Chen, Ganying Chen, Xiaoqing Wang, Xiaoqing Wang, Xianyang Liang, Xianyang Liang, Mengyuan Tan, Mengyuan Tan, Zunnan Huang, Zunnan Huang, Zunnan Huang   +18 more
doaj   +1 more source

Multiplex Immunofluorescence-Based Investigation of the Interventional Effect of Bisdemethoxycurcumin on Glial Cell Polarization in Radiation-Induced Brain Injury

Biomolecules
Radiation-induced brain injury (RIBI) is a severe and common complication following radiotherapy for intracranial tumors, primarily manifested as brain tissue damage, neuroinflammation, and cognitive dysfunction.
Tianrui Zhang, Ziying Geng, Jianhua Chen, Jianhua Li, Zongtai Han, Fangping Han, Jianguo Li   +6 more
doaj   +1 more source

In vitro bactericidal activities of two novel dihydropyridine derivatives against Mycobacterium tuberculosis

Journal of Infection in Developing Countries, 2017
Introduction: Introducing new and effective antitubercular agents is important in tuberculosis control programs. In this study, the in vitro antitubercular activity of two novel 1,4-dihydropyridine derivatives (F-27, Cl-33) were screened against a total
Mehdi Zandhaghighi, Farzin Hadizadeh, Saman Soleimanpour, Zahra Meshkat, Seyed Abdolrahim Rezaee, Mohammad Derakhshan, Kiarash Ghazvini   +6 more
doaj   +1 more source

Evaluation of the Peer Support Program (Student Drug Prevention) 1986-1987

, 2019
The Peer Support program is a school based program funded by the National Campaign Against Drug Abuse (NCADA) as a drug prevention strategy. Prior to the existence of the NCADA the program was funded through the NSW Drug and Alcohol Authority.
Directorate of the Drug Offensive
core   +1 more source

Hydrogel-Based Strategies for the Prevention and Treatment of Radiation-Induced Skin Injury: Progress and Mechanistic Insights

Biomimetics
Radiation-induced skin injury (RISI) is one of the most common complications of radiotherapy, severely compromising patients’ quality of life. However, no standardized treatment has yet been established.
Yinhui Wang, Huan Liu, Yushan He, Mei Li, Jie Gao, Zongtai Han, Jiayu Zhou, Jianguo Li   +7 more
doaj   +1 more source

Pre-Clinical Tools for Predicting Drug Efficacy in Treatment of Tuberculosis

Microorganisms, 2022
Combination therapy has, to some extent, been successful in limiting the emergence of drug-resistant tuberculosis. Drug combinations achieve this advantage by simultaneously acting on different targets and metabolic pathways.
Hasmik Margaryan, Dimitrios D. Evangelopoulos, Leticia Muraro Wildner, Timothy D. McHugh   +3 more
doaj   +1 more source

Drug-drug interactions in the hospital [PDF]

, 2007
Introduction Drug interaction screening programs are an important tool to check prescriptions of multiple drugs for potential drug-drug interactions (pDDIs). Several programs are available on the market.
Vonbach, Priska
core   +1 more source

Biodistribution of AAV1, AAV5, AAV9, and AAVDJ serotypes after intra-cisterna magna delivery in non-human primates

Molecular Therapy: Methods & Clinical Development
Delivering drugs effectively to the central nervous system (CNS) is a major challenge in drug development, including adeno-associated virus (AAV) gene therapy.
Takuro Okai, Sho Sato, Hironobu Yasuno, Miyu Nakayama, Syunsuke Yamamoto, Sebastian Sjöqvist, Kentaro Otake, Masato Nakashima, Mugdha Deshpande, Elizabeth Galbreath, Jeong-Ho Oak, Saku Miyamoto, Gabriele Proetzel   +12 more
doaj   +1 more source