Results 31 to 40 of about 192,321 (310)
BiomimeticsRadiation-induced skin injury (RISI) is one of the most common complications of radiotherapy, severely compromising patients’ quality of life. However, no standardized treatment has yet been established.
Yinhui Wang +7 more
doaj +1 more source
Drug-induced taste disorders in clinical practice and preclinical safety evaluation [PDF]
, 2017 More than 200 medications can induce taste disorders in patients. They not only reduce quality of life for those affected, but can lead to malnutrition, severe dehydration and difficulty in maintaining a therapeutic regimen.
Hummel, Thomas +4 more
core +1 more source
Preclinical Formulation in Early Drug Research [PDF]
, 2011 The success of the drug research and development process depends not only on the intrinsic qualities of the molecules, but also on the way in which these qualities can be revealed.
Ottilia Balazs
core +1 more source
Molecular Therapy: Methods & Clinical DevelopmentDelivering drugs effectively to the central nervous system (CNS) is a major challenge in drug development, including adeno-associated virus (AAV) gene therapy.
Takuro Okai +12 more
doaj +1 more source
Preclinical models for pulmonary drug delivery [PDF]
, 2009 BACKGROUND: The lung comprises an interesting route of administration not only for topical drugs but also for systemically acting drugs. Over the last years, several models have been developed in order to study the efficacy and safety of pulmonary drug ...
Fernandes, Cláudia A., Vanbever, Rita
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Synthesis and Preclinical Evaluation of Radiolabeled [103Ru]BOLD-100 [PDF]
, 2023 The first-in-class ruthenium-based chemotherapeutic agent BOLD-100 (formerly IT-139, NKP-1339, KP1339) is currently the subject of clinical evaluation for the treatment of gastric, pancreatic, colorectal and bile duct cancer.
Thomas L. Mindt +12 more
core +1 more source
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017 The achievements of modern pharmaceutical chemistry allow to develop a wide range of potential new drugs. However, their success in clinical practice depends on their safety. Therefore, the presence of evidence of their safety and efficacy is an integral
T. V. Kravchenko +3 more
doaj +1 more source
Preclinical evaluation of drugs to block inflammation-driven preterm birth [PDF]
Innate Immunity, 2016 Intrauterine inflammation, the major cause of early preterm birth, can have microbial and sterile aetiologies. We assessed in a Transwell model the anti-inflammatory efficacies of five drugs on human extraplacental membranes delivered after preterm spontaneous labour (30–34 wk). Drugs [TPCA1 (IKKβ inhibitor), 5 z-7-oxozeaenol (OxZ,
Demelza J, Ireland +7 more
openaire +2 more sources
A Breath of Fresh Air? Firm Type, Scale, Scope, and Selection Effects in Drug Development [PDF]
, 2009 This paper compares the innovation performance of established pharmaceutical firms and biotech companies, controlling for differences in the scale and scope of research.
Alfonso Gambardella +10 more
core +1 more source
Molecules, 2020 Bedaquiline is a novel drug approved in 2012 by the FDA for treatment of drug-resistant tuberculosis (TB). Although it shows high efficacy towards drug-resistant forms of TB, its use has been limited by the potential for significant side effects.
Peter J. Choi +8 more
doaj +1 more source