Results 21 to 30 of about 8,733,364 (311)

Disease modeling and drug screening using human airway organoids: a systematic review [PDF]

Organoid, 2021
Increasing levels of fine environmental dust particles due to industrialization and emerging respiratory illnesses, such as coronavirus disease 2019, pose serious threats to human life.
Do Hyun Kim, Sung Won Kim
doaj   +1 more source

Supplementary Figure from Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody–drug Conjugate Targeting ADAM9-expressing Tumors

, 2022
Supplementary Figure from Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody–drug Conjugate Targeting ADAM9-expressing ...
Jeff Hooley (15084369), Ying Li (15092440), Richard J. Gregory (15092479), Stuart W. Hicks (15092404), Marian Themeles (15092434), Jacquelynn Lucas (15092419), Kerstin W. Sinkevicius (15092407), Kerry A. McEachem (15092464), Nicholas C. Yoder (15092410), Valentina Ciccarone (15092461), Sergey Gorlatov (15092455), Paul A. Moore (15092473), Deryk Loo (15092485), Megan E. Fuller (15092422), Thomas Son (15092425), Lusiana Widjaja (15092452), Olga Ab (15087715), Thomas Chittenden (15092476), Francine Z. Chen (15092437), James Tamura (15092458), Bhaswati Barat (15092449), Scott Koenig (15092467), Michael Chiechi (15092443), Christopher Espelin (15092431), Jennifer G. Brown (15092416), Gundo Diedrich (15092413), Juniper A. Scribner (15092401), Jenny Lee (15092446), Ezio Bonvini (15092482), Anahita Dastur (15092428), Eric H. Westin (15092470)   +30 more
core   +1 more source

In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity

Frontiers in Pharmacology, 2022
Many medicinal plants species from European -such as Artemisia absinthium, Equisetum arvense, Lamium album, Malva sylvestris, Morus nigra, Passiflora incarnata, Frangula purshiana, and Salix alba- as well as Latin American traditions -such as Libidibia ...
Andre Luis Dias Araujo Mazzari, Mariella Guimarães Lacerda, Flora Aparecida Milton, Flora Aparecida Milton, João Augusto Mulin Montechiari Machado, Simone Batista Pires Sinoti, Anne-Soulene Toullec, Patricia Marquez Rodrigues, Francisco de Assis Rocha Neves, Luiz Alberto Simeoni, Dâmaris Silveira, Jose Maria Prieto, Jose Maria Prieto, Jose Maria Prieto   +13 more
doaj   +1 more source

Enhancing preclinical drug discovery with artificial intelligence

, 2022
Artificial intelligence (AI) is becoming an integral part of drug discovery. It has the potential to deliver across the drug discovery and development value chain, starting from target identification and reaching through clinical development.
Poongavanam, Vasanthanathan, Cross, Jason B., Cross, Jason B.,, Kihlberg, Jan, Vijayan, R. S. K., Vijayan, R. S. K.,, Kihlberg, Jan,, Poongavanam, Vasanthanathan,, Jason B. Cross, R.S.K. Vijayan, Vasanthanathan Poongavanam, Jan Kihlberg   +11 more
core   +1 more source

Combination therapy with bevacizumab and a CCR2 inhibitor for human ovarian cancer: An in vivo validation study

Cancer Medicine, 2023
Background Anti‐angiogenic therapy with bevacizumab (BEV), an anti‐VEGF antibody, plays a critical role in the treatment of ovarian cancer. However, despite an encouraging initial response, most tumors become resistant to BEV over time, and a new ...
Tianyue Zhai, Takashi Mitamura, Lei Wang, Shimpei I. Kubota, Masaaki Murakami, Shinya Tanaka, Hidemichi Watari   +6 more
doaj   +1 more source

The effect of excipients on pharmacokinetic parameters of parenteral drugs [PDF]

, 2005
In the pharmaceutical industry, the main goal of early phase in vivo studies is to assess pharmacokinetic properties of a compound in laboratory animals. These data provide a basis for selecting and optimizing drug candidates.
Egger-Heigold, Barbara
core   +1 more source

A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model

Chinese Medicine, 2021
Background Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang nationality, the largest ethnic minority among 56 nationalities in China.
Qiaofeng Li, Taijin Lan, Songhua He, Weiwei Chen, Xiaolan Li, Weiquan Zhang, Ying Liu, Qiuping Zhang, Xin Chen, Yaoyao Han, Zhiheng Su, Dan Zhu, Hongwei Guo   +12 more
doaj   +1 more source

Drug-Eluting Stents in Preclinical Studies [PDF]

Circulation: Cardiovascular Interventions, 2008
Coronary drug-eluting stents are commonplace in clinical practice with acceptable safety and efficacy. Preclinical evaluation of novel drug-eluting stent technologies has great importance for understanding safety and possibly efficacy of these technologies, and well-defined preclinical testing methods clearly benefit multiple communities within the ...
Robert S, Schwartz, Elazer, Edelman, Renu, Virmani, Andrew, Carter, Juan F, Granada, Greg L, Kaluza, Nicolas A F, Chronos, Keith A, Robinson, Ron, Waksman, Judah, Weinberger, Gregory J, Wilson, Robert L, Wilensky   +11 more
openaire   +2 more sources

Potential Therapies for Cerebral Edema After Ischemic Stroke: A Mini Review

Frontiers in Aging Neuroscience, 2021
Stroke is the leading cause of global mortality and disability. Cerebral edema and intracranial hypertension are common complications of cerebral infarction and the major causes of mortality.
Yi Yao, Yonggang Zhang, Yonggang Zhang, Yonggang Zhang, Xiaoyang Liao, Rong Yang, Yi Lei, Jianzhao Luo   +7 more
doaj   +1 more source

In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice. [PDF]

, 2012
Xenograft mouse models represent helpful tools for preclinical studies on human tumors. For modeling the complexity of the human disease, primary tumor cells are by far superior to established cell lines.
zur Stadt, Udo, Groiss, Volker, Schneider, Katja, Renier J Brentjens, Nadia Terziyska, Harald Ehrhardt, Jeremias, I., Brentjens, Renier J., Farkasova, K., Katja Schneider, Volker Groiss (106787), Katarina Farkasova (106794), Ehrhardt, Harald, Wagner, E., Renier J. Brentjens (106801), Quintanilla-Martinez, Leticia, Martin Horstmann (45040), Ehrhardt, H., Ernst Wagner (60760), Wagner, Ernst, Leticia Quintanilla-Martinez (33277), Terziyska, N., Katja Schneider (106791), Horstmann, M., Brentjens, R.J., Catarina Castro Alves, Quintanilla-Martinez, L., Zur Stadt, U., Horstmann, Martin, Schneider, K., Ogris, M., Manfred Ogris, Alves, C.C., Nadia Terziyska (106777), Terziyska, Nadia, Jeremias, Irmela, Groiss, V., Irmela Jeremias (106806), Volker Groiss, Udo zur Stadt, Martin Horstmann, Farkasova, Katarina, Ernst Wagner, Irmela Jeremias, Ogris, Manfred, Udo zur Stadt (106803), Catarina Castro Alves (106783), Manfred Ogris (60759), Castro Alves, Catarina, Katarina Farkasova, Leticia Quintanilla-Martinez, Harald Ehrhardt (106798)   +51 more
core   +2 more sources