Results 21 to 30 of about 192,321 (310)

Drug-Eluting Stents in Preclinical Studies [PDF]

Circulation: Cardiovascular Interventions, 2008
Coronary drug-eluting stents are commonplace in clinical practice with acceptable safety and efficacy. Preclinical evaluation of novel drug-eluting stent technologies has great importance for understanding safety and possibly efficacy of these technologies, and well-defined preclinical testing methods clearly benefit multiple communities within the ...
Robert S, Schwartz, Elazer, Edelman, Renu, Virmani, Andrew, Carter, Juan F, Granada, Greg L, Kaluza, Nicolas A F, Chronos, Keith A, Robinson, Ron, Waksman, Judah, Weinberger, Gregory J, Wilson, Robert L, Wilensky   +11 more
openaire   +2 more sources

Complement activation as a bioequivalence issue relevant to the development of generic liposomes and other nanoparticulate drugs [PDF]

, 2015
Liposomes are known to activate the complement (C) system, which can lead in vivo to a hypersensitivity syndrome called C activation-related pseudoallergy (CARPA). CARPA has been getting increasing attention as a safety risk of i.v.
Pharmaceutics, Sub Drug targeting, Storm, G, Szebeni, Janos   +3 more
core   +1 more source

Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies [PDF]

, 2014
A major concern in drug development is the characterization of new molecular entities (NMEs) with respect to their safety and efficacy. Both factors are determined by the drug’s exposure within the body which itself is affected by drug clearance ...
Kunze, Annett
core   +1 more source

IC50: an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation

Biomolecules & Biomedicine, 2022
Preclinical models of tumors have the potential to become valuable tools for commercial drug research and development, and 3D culture systems are gaining traction in this area, particularly in prostate cancer (PCa) research.
Yipeng Xu, Gabriela Pachnikova, He Wang, Yaoyao Wu, Dorothea Przybilla, Reinhold Schäfer, Zihao Chen, Shaoxing Zhu, Ulrich Keilholz   +8 more
doaj   +1 more source

Study on Research and Development Status and Application of 90Y Microspheres

Journal of Isotopes, 2022
With 90Y microspheres, radioactive microspheres are perfused to tumor feeding arteries through minimally invasive intervention, and then diffused and retained in small vessels of tumor terminals along with blood flow, so as to high selectively kill tumor
GAO Jie;LIU Xiaoming;ZHOU Wenhua;WANG Hongliang;ZHAO Xiaosheng;GE Qiang;LI Jianguo
doaj  

Innovative preclinical models for pulmonary drug delivery research. [PDF]

, 2020
Introduction: Pulmonary drug delivery is a complex field of research combining physics which drive aerosol transport and deposition and biology which underpins efficacy and toxicity of inhaled drugs.
Vecellio, L., Barosova, Hana, Schmid, O., Schmid, Otmar, Sznitman, Josue, Vecellio, Laurent, Barosova, H., Rothen-Rutishauser, Barbara, Yang, L., Sznitman, J., Henze-Vourc´h, N., Yang, Lin, Ehrmann, S., Mitchell, Jolyon, Heuzé-Vourc'H, Nathalie, Ehrmann, Stephan, Darquenne, Chantal, Heuze-Vourc’h, Nathalie, Darquenne, C., Mitchell, J., Rothen-Rutishauser, B.   +20 more
core   +1 more source

Computational Approaches in Preclinical Studies on Drug Discovery and Development

Frontiers in Chemistry, 2020
Because undesirable pharmacokinetics and toxicity are significant reasons for the failure of drug development in the costly late stage, it has been widely recognized that drug ADMET properties should be considered as early as possible to reduce failure ...
Fengxu Wu, Fengxu Wu, Yuquan Zhou, Yuquan Zhou, Langhui Li, Langhui Li, Xianhuan Shen, Xianhuan Shen, Ganying Chen, Ganying Chen, Xiaoqing Wang, Xiaoqing Wang, Xianyang Liang, Xianyang Liang, Mengyuan Tan, Mengyuan Tan, Zunnan Huang, Zunnan Huang, Zunnan Huang   +18 more
doaj   +1 more source

Preclinical in vivo Neurotoxicity Studies of Drug Candidates [PDF]

, 2020
Neurotoxic effects are one of the common reasons for discontinuation of preclinical and/or clinical studies. Preclinical evaluation of neurotoxic effects is complicated due to a wide range of manifestations and degrees of severity.
L. G. Kolik, R. U. Ostrovskaya, A. D. Durnev, N. V. Eremina   +3 more
core   +2 more sources

In vitro bactericidal activities of two novel dihydropyridine derivatives against Mycobacterium tuberculosis

Journal of Infection in Developing Countries, 2017
Introduction: Introducing new and effective antitubercular agents is important in tuberculosis control programs. In this study, the in vitro antitubercular activity of two novel 1,4-dihydropyridine derivatives (F-27, Cl-33) were screened against a total
Mehdi Zandhaghighi, Farzin Hadizadeh, Saman Soleimanpour, Zahra Meshkat, Seyed Abdolrahim Rezaee, Mohammad Derakhshan, Kiarash Ghazvini   +6 more
doaj   +1 more source

Pre-Clinical Tools for Predicting Drug Efficacy in Treatment of Tuberculosis

Microorganisms, 2022
Combination therapy has, to some extent, been successful in limiting the emergence of drug-resistant tuberculosis. Drug combinations achieve this advantage by simultaneously acting on different targets and metabolic pathways.
Hasmik Margaryan, Dimitrios D. Evangelopoulos, Leticia Muraro Wildner, Timothy D. McHugh   +3 more
doaj   +1 more source