Results 11 to 20 of about 307,974 (304)

Advances in preclinical evaluation of experimental antibody-drug conjugates

Cancer Drug Resistance, 2021
The ability to chemically modify monoclonal antibodies with the attachment of specific functional groups has opened up an enormous range of possibilities for the targeted treatment and diagnosis of cancer in the clinic. As the number of such antibody-based drug candidates has increased, so too has the need for more stringent and robust preclinical ...
Lyons, Scott K, Plenker, Dennis, Trotman, Lloyd C   +2 more
openaire   +4 more sources

Combination therapy with bevacizumab and a CCR2 inhibitor for human ovarian cancer: An in vivo validation study

Cancer Medicine, 2023
Background Anti‐angiogenic therapy with bevacizumab (BEV), an anti‐VEGF antibody, plays a critical role in the treatment of ovarian cancer. However, despite an encouraging initial response, most tumors become resistant to BEV over time, and a new ...
Tianyue Zhai, Takashi Mitamura, Lei Wang, Shimpei I. Kubota, Masaaki Murakami, Shinya Tanaka, Hidemichi Watari   +6 more
doaj   +1 more source

EO9 (Apaziquone): from the clinic to the laboratory and back again [PDF]

, 2013
EO9 (Apaziquone) is a bioreductive drug that has a chequered history. It underwent clinical trial but failed to show activity in phase II clinical trials when administered i.v.
Aamdal, Adams, Bailey, Bailey, Basu, Bibby, Bibby, Burd, Butler, Cadenas, Ceelen, Choudry, Collard, Connors, Cowan, Cummings, Denny, Dirix, Ernster, Fitzsimmons, Gofrit, Hall, Hargreaves, Hay, Hay, Hay, Hendricksen, Hendricksen, Hendriks, Jain, Loadman, Lu, Maliepaard, Masters, Masters, McKeown, McLeod, Milbank, Minchinton, Oostveen, Pavlidis, Phillips, Phillips, Phillips, Phillips, Phillips, Phillips, Pizao, Plumb, Plumb, Plumb, Puri, Rademakers, Robertson, Robertson, Roed, Schellens, Segura-Aguilar, Siegel, Siegel, Smitskamp-Wilms, Stratford, Sylvester, Tercel, van der Heijden, van der Schoot, van der Schoot, van der Schoot, Vaupel, Vaupel, Walton, Walton, Workman, Workman, Workman, Zappa   +75 more
core   +1 more source

A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model

Chinese Medicine, 2021
Background Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang nationality, the largest ethnic minority among 56 nationalities in China.
Qiaofeng Li, Taijin Lan, Songhua He, Weiwei Chen, Xiaolan Li, Weiquan Zhang, Ying Liu, Qiuping Zhang, Xin Chen, Yaoyao Han, Zhiheng Su, Dan Zhu, Hongwei Guo   +12 more
doaj   +1 more source

Drug-Eluting Stents in Preclinical Studies [PDF]

Circulation: Cardiovascular Interventions, 2008
Coronary drug-eluting stents are commonplace in clinical practice with acceptable safety and efficacy. Preclinical evaluation of novel drug-eluting stent technologies has great importance for understanding safety and possibly efficacy of these technologies, and well-defined preclinical testing methods clearly benefit multiple communities within the ...
Robert S, Schwartz, Elazer, Edelman, Renu, Virmani, Andrew, Carter, Juan F, Granada, Greg L, Kaluza, Nicolas A F, Chronos, Keith A, Robinson, Ron, Waksman, Judah, Weinberger, Gregory J, Wilson, Robert L, Wilensky   +11 more
openaire   +2 more sources

Potential Therapies for Cerebral Edema After Ischemic Stroke: A Mini Review

Frontiers in Aging Neuroscience, 2021
Stroke is the leading cause of global mortality and disability. Cerebral edema and intracranial hypertension are common complications of cerebral infarction and the major causes of mortality.
Yi Yao, Yonggang Zhang, Yonggang Zhang, Yonggang Zhang, Xiaoyang Liao, Rong Yang, Yi Lei, Jianzhao Luo   +7 more
doaj   +1 more source

IC50: an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation

Biomolecules & Biomedicine, 2022
Preclinical models of tumors have the potential to become valuable tools for commercial drug research and development, and 3D culture systems are gaining traction in this area, particularly in prostate cancer (PCa) research.
Yipeng Xu, Gabriela Pachnikova, He Wang, Yaoyao Wu, Dorothea Przybilla, Reinhold Schäfer, Zihao Chen, Shaoxing Zhu, Ulrich Keilholz   +8 more
doaj   +1 more source

Evaluation of melanin-targeted radiotherapy in combination with radiosensitizing drugs for the treatment of melanoma [PDF]

, 2014
The incidence of malignant melanoma is rising faster than that of any other cancer in the United States. An [131I]-labeled benzamide - [131I]MIP-1145 - selectively targets melanin, reduces melanoma tumor burden and increases survival in preclinical ...
Babich, John, Boyd, Marie, Hutchison, Sharon, Mairs, Robert, Rae, Colin, Tesson, Mathias   +5 more
core   +1 more source

Study on Research and Development Status and Application of 90Y Microspheres

Journal of Isotopes, 2022
With 90Y microspheres, radioactive microspheres are perfused to tumor feeding arteries through minimally invasive intervention, and then diffused and retained in small vessels of tumor terminals along with blood flow, so as to high selectively kill tumor
GAO Jie;LIU Xiaoming;ZHOU Wenhua;WANG Hongliang;ZHAO Xiaosheng;GE Qiang;LI Jianguo
doaj  

Guidelines for the recording and evaluation of pharmaco-EEG data in man: the International Pharmaco-EEG Society (IPEG) [PDF]

, 2012
The International Pharmaco-EEG Society (IPEG) presents updated guidelines summarising the requirements for the recording and computerised evaluation of pharmaco-EEG data in man.
BABILONI, CLAUDIO, Boeijinga PH, Brunovsky M, Drinkenburg WH, Ffytche DH, Freeman J, Hegerl U, Hirata K, IPEG Pharmaco EEG Guidelines C.o.m.m.i.t.t.e.e. Collaborators, Jobert M, Kinoshita T, Knott VJ, Lopes Da Silva FH, Matousek M, Mucci A, Nottage JF, Olbrich S, Prichep LS, Ruigt GS, Saletu B, Stancak A, Strik WK, van Gerven JM, Wilson FJ, Wise RG   +24 more
core   +1 more source