Comparative evaluation of recommendations for preclinical studies of transporter-mediated drug–drug interactions [PDF]
Регуляторные исследования и экспертиза лекарственных средств, 2023 Scientific relevance. Sound recommendations for preclinical studies of transporter- mediated pharmacokinetic interactions of medicinal products can help increase the likelihood of identifying potentially nephrotoxic and hepatotoxic medicinal products at ...
V. A. Evteev +3 more
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EXPERT EVALUATION OF PRECLINICAL STUDIES OF PRIMARY AND SECONDARY PHARMACODYNAMICS OF MEDICINES [PDF]
Регуляторные исследования и экспертиза лекарственных средств, 2018 The article dwells upon the results of comparative analysis of the Russian national requirements and EAEU regulations dealing with evaluation of preclinical pharmacological studies.
G. N. Engalycheva +3 more
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Supplementary Data from Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody–drug Conjugate Targeting ADAM9-expressing Tumors [PDF]
, 2022 Supplementary Data from Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody–drug Conjugate Targeting ADAM9-expressing ...
Jeff Hooley (15084369) +30 more
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Supplementary Figure from Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody–drug Conjugate Targeting ADAM9-expressing Tumors [PDF]
, 2022 Supplementary Figure from Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody–drug Conjugate Targeting ADAM9-expressing ...
Jeff Hooley (15084369) +30 more
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A Novel Human Multi-Tissue System For Preclinical Drug Evaluation And Recapitulation Of Metastasis [PDF]
, 2022 The drug development process, especially for anti-cancer therapies, continues to be highly inefficient. The current preclinical drug evaluation paradigm of human monolayer in vitro culture followed by small animal in vivo models results in a roughly 90 ...
Chramiec, Alan
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In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice. [PDF]
, 2012 Xenograft mouse models represent helpful tools for preclinical studies on human tumors. For modeling the complexity of the human disease, primary tumor cells are by far superior to established cell lines.
zur Stadt, Udo +51 more
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The effect of excipients on pharmacokinetic parameters of parenteral drugs [PDF]
, 2005 In the pharmaceutical industry, the main goal of early phase in vivo studies is to assess pharmacokinetic properties of a compound in laboratory animals. These data provide a basis for selecting and optimizing drug candidates.
Egger-Heigold, Barbara
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Drug-Homogeneity Index in Mass-Spectrometry Imaging [PDF]
, 2018 Enhancing drug penetration in solid tumors is an interesting clinical issue of considerable importance. In preclinical research, mass-spectrometry imaging is a promising technique for visualizing drug distribution in tumors under different treatment ...
Francesca Falcetta (473387) +19 more
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Characterization of phototoxicity reactions in human and animal skin models [PDF]
, 2013 Phototoxicity is a relatively common phenomenon and is an adverse effect of some systemic drugs. A large number of pharmaceutical drug substances are known to carry the potential to elicit a phototoxic response (Moore 2002, Ferguson 2002). Reported cases
Boudon, Stéphanie
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Potential Therapies for Cerebral Edema After Ischemic Stroke: A Mini Review
Frontiers in Aging Neuroscience, 2021 Stroke is the leading cause of global mortality and disability. Cerebral edema and intracranial hypertension are common complications of cerebral infarction and the major causes of mortality.
Yi Yao +7 more
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