Results 41 to 50 of about 192,321 (310)

Effects of a new thyrotropic drug isolated from Potentilla alba on the male reproductive system of rats and offspring development

BMC Complementary Medicine and Therapies, 2021
Background The dysfunction of the thyroid gland is a common medical condition. Nowadays, patients frequently use medicinal herbs as complementary or alternative options to conventional drug treatments. These patients may benefit from treatment of thyroid
Lubov V. Krepkova, Valentina V. Bortnikova, Aleksandra N. Babenko, Praskovya G. Mizina, Vladimir A. Mkhitarov, Kathleen M. Job, Catherine M. Sherwin, Elena Y. Enioutina   +7 more
doaj   +1 more source

Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era

Disease Models & Mechanisms, 2014
The current preclinical pipeline for drug discovery can be cumbersome and costly, which limits the number of compounds that can effectively be transitioned to use as therapies.
Chansey J. Veinotte, Graham Dellaire, Jason N. Berman   +2 more
doaj   +1 more source

Bridging the Gap in Neuroblastoma Care: Consensus‐Based Statements With Recommendations for Improved Patient and Caregiver Experiences

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neuroblastoma's complex, heterogeneous biology poses significant diagnostic and therapeutic challenges, often requiring caregivers to absorb complex information and participate in time‐sensitive decisions. However, caregivers often feel unprepared to evaluate options.
Vickie Buenger, Joseph Bauer, Jennifer Diamond, Maggie Fader, Shae Hansen, Jacqueline M. Kraveka, Johanna Schoen, Amber Shearer, Dena Sherwood   +8 more
wiley   +1 more source

Considerations in biodistribution evaluation of iPSC-derived cell therapy: A pancreatic islet cell case study

Molecular Therapy: Methods & Clinical Development
Induced pluripotent stem cells (iPSCs) have substantial transformative potential in regenerative medicine, enabling tissue repair and restoration.
Miyu Nakayama, Yuu Moriya, Hikaru Ueno, Takeshi Watanabe, Hideki Hirabayashi, Syunsuke Yamamoto   +5 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Endogenous Biomarkers for SLC Transporter-Mediated Drug-Drug Interaction Evaluation [PDF]

, 2021
Membrane transporters play an important role in the absorption, distribution, metabolism, and excretion of xenobiotic substrates, as well as endogenous compounds.
Xihui Chen, Shuiying Hu, Yang Li, Zahra Talebi, Alex Sparreboom   +4 more
core   +1 more source

Narciclasine induces colon carcinoma cell apoptosis by inhibiting the IL-17A/Act1/TRAF6/NF-κB signaling pathway

Genes and Diseases
IL-17 A is a promoter of colorectal cancer initiation and progression. Narciclasine is a polyhydroxy alkaloid compound isolated from Narcissus plants, which has potent anti-inflammatory and antitumor actions.
Huiming Deng, Qiang Liu, Siman Yu, Lifan Zhong, Lianfang Gan, Huiquan Gu, Qianru Wang, Ruxin Cheng, Yong Liu, Li Liu, Ling Huang, Ronghua Xu   +11 more
doaj   +1 more source

Replacement, Reduction, and Refinement of Animal Experiments in Anticancer Drug Development: The Contribution of 3D In Vitro Cancer Models in the Drug Efficacy Assessment

Biomedicines, 2023
In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold standards in the preclinical assessment of anticancer drug efficacy. 3D in vitro
Elena M. Tosca, Davide Ronchi, Daniele Facciolo, Paolo Magni   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Targeted nanomedicines for the treatment of inflammatory disorders and cancer [PDF]

, 2012
The therapeutic value of various targeted nanomedicines was evaluated in several inflammatory disorders, including cancer, while exploring which nanocarrier may be most suitable for a specific therapeutic application. First, an overview of drug targeting
Pharmaceutics, Dep Farmaceutische wetenschappen, Crielaard, B.J., Sub Drug targeting, Advanced drug delivery systems/drug targeting   +4 more
core