Results 41 to 50 of about 8,733,364 (311)
Preclinical evaluation of drugs to block inflammation-driven preterm birth [PDF]
Innate Immunity, 2016 Intrauterine inflammation, the major cause of early preterm birth, can have microbial and sterile aetiologies. We assessed in a Transwell model the anti-inflammatory efficacies of five drugs on human extraplacental membranes delivered after preterm spontaneous labour (30–34 wk). Drugs [TPCA1 (IKKβ inhibitor), 5 z-7-oxozeaenol (OxZ,
Demelza J, Ireland +7 more
openaire +2 more sources
Preclinical in vivo Neurotoxicity Studies of Drug Candidates [PDF]
, 2020 Neurotoxic effects are one of the common reasons for discontinuation of preclinical and/or clinical studies. Preclinical evaluation of neurotoxic effects is complicated due to a wide range of manifestations and degrees of severity.
L. G. Kolik +3 more
core +1 more source
Preclinical pharmacokinetic evaluation of novel antimalarial and antituberculosis drug leads [PDF]
, 2019 Preclinical pharmacokinetics relies on efficient and accurate screening to select clinical candidates from early leads. Poor pharmacokinetic interpretation can disadvantage drug discovery by promoting inadequate compounds and expelling potential drug ...
Strydom, Natasha
core +1 more source
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017 The achievements of modern pharmaceutical chemistry allow to develop a wide range of potential new drugs. However, their success in clinical practice depends on their safety. Therefore, the presence of evidence of their safety and efficacy is an integral
T. V. Kravchenko +3 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh +4 more
wiley +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Instruction Tenapanor potentially affects fluid volume and blood pressure. This study explored its effects on these parameters in patients undergoing peritoneal dialysis (PD). Methods We conducted a single‐arm, prospective observational study that enrolled 10 patients on PD with hyperphosphatemia who were newly initiated on tenapanor.
Shun Yoshida +11 more
wiley +1 more source
A Novel Human Multi-Tissue System For Preclinical Drug Evaluation And Recapitulation Of Metastasis [PDF]
, 2022 The drug development process, especially for anti-cancer therapies, continues to be highly inefficient. The current preclinical drug evaluation paradigm of human monolayer in vitro culture followed by small animal in vivo models results in a roughly 90 ...
Chramiec, Alan
core +1 more source
Molecular Therapy: Methods & Clinical DevelopmentInduced pluripotent stem cells (iPSCs) have substantial transformative potential in regenerative medicine, enabling tissue repair and restoration.
Miyu Nakayama +5 more
doaj +1 more source
ALTEX: Alternatives to Animal Experimentation, 2008 Human-based in vitro hepatic experimental systems are now used routinely in drug development. The rationale for the use of humanbased in vitro systems is based on the known species-species differences in drug properties.
Albert P. Li
doaj +1 more source
BMC Complementary Medicine and Therapies, 2021 Background The dysfunction of the thyroid gland is a common medical condition. Nowadays, patients frequently use medicinal herbs as complementary or alternative options to conventional drug treatments. These patients may benefit from treatment of thyroid
Lubov V. Krepkova +7 more
doaj +1 more source