Results 61 to 70 of about 1,227,969 (402)
A Deep Bayesian Bandits Approach for Anticancer Therapy: Exploration via Functional Prior [PDF]
arXiv, 2022 Learning personalized cancer treatment with machine learning holds great promise to improve cancer patients' chance of survival. Despite recent advances in machine learning and precision oncology, this approach remains challenging as collecting data in preclinical/clinical studies for modeling multiple treatment efficacies is often an expensive, time ...
arxiv
Current and Future Issues in the Development of Spinal Agents for the Management of Pain. [PDF]
, 2017 Targeting analgesic drugs for spinal delivery reflects the fact that while the conscious experience of pain is mediated supraspinally, input initiated by high intensity stimuli, tissue injury and/or nerve injury is encoded at the level of the spinal ...
Fisher, Casey J +3 more
core +2 more sources
Science Advances, 2020 A novel mouse model of chronic ear infections is used to investigate antibiotic failure in humans. Chronic suppurative otitis media (CSOM) is a neglected pediatric disease affecting 330 million worldwide for which no new drugs have been introduced for ...
K. Khomtchouk +9 more
semanticscholar +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Preclinical evaluation of a GFRA1 targeted antibody-drug conjugate in breast cancer [PDF]
Oncotarget, 2018 Despite recent advances in treatment, breast cancer remains the second-most common cause of cancer death among American women. A greater understanding of the molecular characteristics of breast tumors could ultimately lead to improved tumor-targeted treatment options, particularly for subsets of breast cancer patients with unmet needs.
David A. Tice +24 more
openaire +3 more sources
DiseasesBackground: O6-Methylguanine-DNA methyltransferase (MGMT) is a unique antimutagenic DNA repair protein that plays a crucial role in conferring resistance to various alkylating agents in brain tumor therapy.
Debasish Basak +3 more
doaj +1 more source
The benefits, limitations and opportunities of preclinical models for neonatal drug development
Disease Models & Mechanisms, 2022 Increased research to improve preclinical models to inform the development of therapeutics for neonatal diseases is an area of great need. This article reviews five common neonatal diseases – bronchopulmonary dysplasia, retinopathy of prematurity ...
Sarah Campion +18 more
doaj +1 more source
Clinical connectivity map for drug repurposing: using laboratory tests to bridge drugs and diseases [PDF]
arXiv, 2020 Drug repurposing has attracted increasing attention from both the pharmaceutical industry and the research community. Many existing computational drug repurposing methods rely on preclinical data (e.g., chemical structures, drug targets), resulting in translational problems for clinical trials.
arxiv
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Microorganisms, 2022 In the absence of drugs to treat or prevent COVID-19, drug repurposing can be a valuable strategy. Despite a substantial number of clinical trials, drug repurposing did not deliver on its promise.
Frauke Assmus +30 more
doaj +1 more source