Results 131 to 140 of about 6,725,081 (364)

Radioiodinated Tau Imaging Agent III Molecular Modeling, Synthesis, and Evaluation of a New Tau Imaging Agent, [¹²⁵I]ISAS in Post-Mortem Human Alzheimer’s Disease Brain

Molecules
Using a molecular modeling approach for Tau-binding sites, we modified our previously reported imaging agent, [125I]INFT, for the potential improvement of binding properties to Tau in an Alzheimer’s disease (AD) brain.
Stephanie A. Sison, Cayz G. Paclibar, Christopher Liang, Jogeshwar Mukherjee   +3 more
doaj   +1 more source

Addressing the needs of traumatic brain injury with clinical proteomics. [PDF]

, 2014
BackgroundNeurotrauma or injuries to the central nervous system (CNS) are a serious public health problem worldwide. Approximately 75% of all traumatic brain injuries (TBIs) are concussions or other mild TBI (mTBI) forms.
Loo, Joseph A, Loo, Rachel R Ogorzalek, Shen, Sean, Wanner, Ina-Beate   +3 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

6th Internatinal TPCF Preclinical Imaging Symposium

Frontiers in Biomedical Technologies
As we step into 2023, the landscape of translational medicine continues to evolve, revealing the profound importance of preclinical imaging in bridging the gap between laboratory discoveries and clinical applications.
6 th Internatinal TPCF Preclinical Imaging
doaj  

[¹⁸F]Mefway: Imaging Serotonin 5HT_1A Receptors in Human Postmortem Alzheimer’s and Parkinson’s Disease Anterior Cingulate. Potential Applications to Human Positron Emission Tomography Studies

Biomolecules
Serotonin 5HT1A receptors may be affected in neurodegeneration, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Using the selective 5HT1A receptor positron emission tomography (PET) imaging agent, [18F]mefway, autoradiographic studies from
Noresa L. Gonzaga, Fariha Karim, Christopher Liang, Jogeshwar Mukherjee   +3 more
doaj   +1 more source

Pharmacokinetics and tumor dynamics of the nanoparticle IT-101 from PET imaging and tumor histological measurements [PDF]

, 2009
IT-101, a cyclodextrin polymer-based nanoparticle containing camptothecin, is in clinical development for the treatment of cancer. Multiorgan pharmacokinetics and accumulation in tumor tissue of IT-101 is investigated by using PET.
Alley, B. C. Mack, Braet, C. A. Alabi, C. H. J. Choi, Carter, Cheng, Cheng, Davis, Davis, Dreher, Drummond, Hashizume, Heidel, Hobbs, I. J. Hildebrandt, J. Czernin, J. Hwang, Kirpotin, Loening, M. E. Davis, Matsumura, Moore, O'Connor, Reddy, Riches, Schluep, Schluep, Schluep, T. Schluep, Tabata, Tirona, Torchilin, Yuan   +33 more
core   +3 more sources

Laparoscopic fluorescence imaging technique for visualizing biliary structures using sodium fluorescein: the result of a preclinical study in a porcine model

, 2023
Sungho Kim, Chang Min Lee, Yoontaek Lee, Hyung Joon Han, Tae-Jin Song   +4 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

7th International Conference on Preclinical Imaging Applications

Frontiers in Biomedical Technologies
As we embrace 2024, the field of translational medicine stands at an exciting crossroads where innovation, collaboration, and cutting-edge technology converge.
7 th International TPCF Preclinical Imaging
doaj  

Comparison of [11C]TZ1964B and [18F]MNI659 for PET imaging brain PDE10A in nonhuman primates [PDF]

, 2016
Phosphodiesterase 10A (PDE10A) inhibitors show therapeutic effects for diseases with striatal pathology. PET radiotracers have been developed to quantify in vivo PDE10A levels and target engagement for therapeutic interventions. The aim of this study was
Alagille, David, Flores, Hubert, Han, Junbin, Jin, Hongjun, Liu, Hui, Perlmutter, Joel S, Su, Yi, Tamagnan, Gilles, Tu, Zhude, Yang, Hao, Yue, Xuyi   +10 more
core   +2 more sources