Results 21 to 30 of about 6,725,081 (364)

Preclinical Lymphatic Imaging [PDF]

Molecular Imaging and Biology, 2010
Noninvasive in vivo imaging of lymphatic vessels and lymphatic nodes is expected to fulfill the purpose of analyzing lymphatic vessels and their function, understanding molecular mechanisms of lymphangiogenesis and lymphatic spread of tumors, and utilizing lymphatic molecular markers as a prognostic or diagnostic indicator. In this review, we provide a
Fan, Zhang, Gang, Niu, Guangming, Lu, Xiaoyuan, Chen   +3 more
openaire   +2 more sources

Covalent ¹⁸F-Radiotracers for SNAPTag: A New Toolbox for Reporter Gene Imaging

Pharmaceuticals, 2021
There is a need for versatile in vivo nuclear imaging reporter systems to foster preclinical and clinical research. We explore the applicability of the SNAPTag and novel radiolabeled small-molecule ligands as a versatile reporter gene system for in vivo ...
Sophie Stotz, Gregory D. Bowden, Jonathan M. Cotton, Bernd J. Pichler, Andreas Maurer   +4 more
doaj   +1 more source

Measurement of Aβ Amyloid Plaques and Tau Protein in Postmortem Human Alzheimer’s Disease Brain by Autoradiography Using [¹⁸F]Flotaza, [¹²⁵I]IBETA, [^124/125I]IPPI and Immunohistochemistry Analysis Using QuPath

Biomedicines, 2023
High-resolution scans of immunohistochemical (IHC) stains of Alzheimer’s disease (AD) brain slices and radioligand autoradiography both provide information about the distribution of Aβ plaques and Tau, the two common proteinopathies in AD.
Rommani Mondal, Yasmin K. Sandhu, Vallabhi M. Kamalia, Brooke A. Delaney, Amina U. Syed, Grace A. H. Nguyen, Taylor R. Moran, Roz R. Limpengco, Christopher Liang, Jogeshwar Mukherjee   +9 more
doaj   +1 more source

Synthesis and Biological Evaluation of a Radiolabeled PET (Positron Emission Tomography) Probe for Visualization of In Vivo α-Fucosidase Expression

Pharmaceuticals, 2021
The acidic hydrolase α-fucosidase (AF) is a biomarker for maladies such as cancer and inflammation. The most advanced probes for α-fucosidase are unfortunately constrained to ex vivo or in vitro applications.
Jonathan Cotton, Chris Marc Goehring, Anna Kuehn, Andreas Maurer, Kerstin Fuchs, Bernd J. Pichler   +5 more
doaj   +1 more source

Glutamate’s Effects on the N-Methyl-D-Aspartate (NMDA) Receptor Ion Channel in Alzheimer’s Disease Brain: Challenges for PET Radiotracer Development for Imaging the NMDA Ion Channel

Molecules, 2023
In an effort to further understand the challenges facing in vivo imaging probe development for the N-methyl-D-aspartate (NMDA) receptor ion channel, we have evaluated the effect of glutamate on the Alzheimer’s disease (AD) brain.
Nehal M. Shah, Nane Ghazaryan, Noresa L. Gonzaga, Cayz G. Paclibar, Agnes P. Biju, Christopher Liang, Jogeshwar Mukherjee   +6 more
doaj   +1 more source

Characterization of an APP/tau rat model of Alzheimer’s disease by positron emission tomography and immunofluorescent labeling

Alzheimer’s Research & Therapy, 2021
Background To better understand the etiology and pathomechanisms of Alzheimer’s disease, several transgenic animal models that overexpress human tau or human amyloid-beta (Aβ) have been developed. In the present study, we generated a novel transgenic rat
Thomas Filip, Severin Mairinger, Joerg Neddens, Michael Sauberer, Stefanie Flunkert, Johann Stanek, Thomas Wanek, Nobuyuki Okamura, Oliver Langer, Birgit Hutter-Paier, Claudia Kuntner   +10 more
doaj   +1 more source

Biomarkers in preclinical cancer imaging [PDF]

European Journal of Nuclear Medicine and Molecular Imaging, 2015
In view of the trend towards personalized treatment strategies for (cancer) patients, there is an increasing need to noninvasively determine individual patient characteristics. Such information enables physicians to administer to patients accurate therapy with appropriate timing.
Bernsen, M.R., Kooiman, K., Segbers, M., Leeuwen, F.W.B. van, Jong, M. de   +4 more
openaire   +4 more sources

Micro-ultrasound for preclinical imaging [PDF]

Interface Focus, 2011
Over the past decade, non-invasive preclinical imaging has emerged as an important tool to facilitate biomedical discovery. Not only have the markets for these tools accelerated, but the numbers of peer-reviewed papers in which imaging end points and biomarkers have been used have grown dramatically.
F Stuart, Foster, John, Hossack, S Lee, Adamson   +2 more
openaire   +2 more sources

Development of [^124/125I]IAZA as a New Proteinopathy Imaging Agent for Alzheimer’s Disease

Molecules, 2023
Radioiodinated imaging agents for Aβ amyloid plaque imaging in Alzheimer’s disease (AD) patients have not been actively pursued. Our previous studies employed the “diaza” derivatives [11C]TAZA and [18F]flotaza in order to develop successful positron ...
Thrisha T. Reddy, Michael H. Iguban, Lusine L. Melkonyan, Jasmine Shergill, Christopher Liang, Jogeshwar Mukherjee   +5 more
doaj   +1 more source

Quality and validity of large animal experiments in stroke : a systematic review [PDF]

, 2020
An important factor for successful translational stroke research is study quality. Low-quality studies are at risk of biased results and effect overestimation, as has been intensely discussed for small animal stroke research.
Bahor, Z., Boltze, Johannes, Herrmann, A. M., Kringe, L., Meckel, S., Motschall, E., Mülling, C., Sena, E. S., Wang, Q.   +8 more
core   +4 more sources