Results 211 to 220 of about 777,237 (284)

A call to action to address critical flaws and bias in laboratory animal experiments and preclinical research. [PDF]

Sci Rep
Townsend HGG, Osterrieder K, Jelinski MD, Morck DW, Waldner CL, Cox WR, Gerdts V, Potter AA, Babiuk LA, Cross JC.   +9 more
europepmc   +1 more source

Automating Vascular Biology: An End‐to‐End Automated Workflow for High‐Throughput Blood Vessel‐on‐a‐Chip Production and Multi‐Site Validation

Advanced Healthcare Materials, EarlyView.
AngioPlate384 is a 384‐well open‐top platform that automates production of more than 100 miniaturized, perfusable blood vessels embedded in hydrogel and supported by stromal cells. Stromal‐endothelial co‐culture strengthens blood vessel barrier function and yields responses useful for translational planning. Scalable and automation‐ready, it suits drug
Dawn S. Y. Lin, Hanieh Mohammad Hashemi, Kimia Asadi Jozani, Anushree Chakravarty, Sonya Kouthouridis, Jessica Bonanno, Nicky Anvari, Shravanthi Rajasekar, Feng Zhang, Richard Y. Cheng, Narendra Kumar Singh, Luis Miguel Medina, Marc Durante, Yufang He, Boyang Zhang   +14 more
wiley   +1 more source

Nuclear Imaging Strategies to Evaluate Cytokine Production in Autoimmune, Inflammatory, and Neoplastic Diseases: A Review of Current Preclinical Research. [PDF]

J Nucl Med
Deck A, Lane S, Liles A, Viola NT.
europepmc   +1 more source

Taming the Immiscibility of Gold, Iron, and Boron to Craft Chemodegradable Nanoparticles for Multimodal Imaging and Radiotherapy

Advanced Healthcare Materials, EarlyView.
Over half of cancer patients undergo radiotherapy. Laser ablation enabled the synthesis of immiscible Au‐Fe‐B nanoparticles designed as degradable bimodal radiosensitizers for X‐ray radiotherapy (XRT), boron neutron capture therapy (BNCT), and bimodal imaging for X‐ray computed tomography (CT) and magnetic resonance imaging (MRI). These nanosensitizers
Michael Bissoli, Clara M.G. de Faria, Veronica Torresan, Maria Assunta Lacavalla, Mattia Cattelan, Denis Badocco, Paolo Pastore, Pasquina Marzola, Laura Cansolino, Cinzia Ferrari, Ian Postuma, Riccardo Vago, Silva Bortolussi, Antonello E. Spinelli, Daniel Forrer, Vincenzo Amendola   +15 more
wiley   +1 more source

Preclinical Research in McArdle Disease

McArdle disease is an autosomal recessive disorder of muscle glycogen metabolism caused by pathogenic mutations in the PYGM gene, which encodes the skeletal muscle-specific isoform of glycogen phosphorylase. Clinical symptoms are mainly characterized by transient acute "crises" of early fatigue, myalgia and contractures, which can be accompanied by ...
Villarreal-Salazar, Mónica||, Brull, Astrid||, Nogales, Gisela||, Andreu Périz, Antoni Lluís, Martín, Miguel Angel||, Arenas, Joaquín||, Santalla, Alfredo||, Lucia, Alejandro||, Vissing, John||, Krag, Thomas||, Pinós Figueras, Tomàs||   +10 more
openaire   +1 more source

Testing the usefulness of a quality system in preclinical research. [PDF]

Neurosci Appl
Bernard R, Gerlach B, Haas M, Macleod M, Potschka H, Rice ASC, Steckler T, Voikar V, Wever KE.   +8 more
europepmc   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Why non-human primates are needed in stroke preclinical research. [PDF]

Stroke Vasc Neurol
Long X, Zeng J.
europepmc   +1 more source

Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects

Advanced Healthcare Materials, EarlyView.
Bacterial infection is a major driver of delayed wound healing and postsurgical readmissions; with rising antibiotic resistance, solid peroxide–releasing biomaterials offer sustained delivery of ROS/O2 for antimicrobial control and microenvironmental modulation.
Ayden Watt, Chably Rachella, Charlotte Jaloux, Joshua Vorstenbosch, Adam Hart, Michael Tanzer, Geraldine Merle, Jake Barralet   +7 more
wiley   +1 more source

Preclinical research in obesity-associated metabolic diseases using in vitro, multicellular, and non-mammalian models. [PDF]

J Physiol Biochem
Aranaz P, Clavel-Millan M, Gil-Cardoso K, González-Arceo M, Hernández-González D, Les F, Salles J, Amri EZ, Arbones-Mainar JM, Atgié C, Capel F, Courtois A, Escoté X, García-Barrado MJ, Krisa S, López V, Milagro FI, Portillo MP, Lorente-Cebrián S.   +18 more
europepmc   +1 more source