Results 221 to 230 of about 790,668 (339)

A brief guide to statistical analysis of grouped data in preclinical research. [PDF]

Nat Metab
Vorland CJ, Golzarri-Arroyo L, Allison DB.   +2 more
europepmc   +1 more source

Prospective system analysis of the pre- and early hospital care in severe head injury in Bavaria at a population-based level [PDF]

, 2002
Baethmann, Alexander, Schlesinger-Raab, Anne, Wirth, A.   +2 more
core   +1 more source

Biomimetic Copper‐Doped Nano‐Aluminum Adjuvant Potentiates Therapy in Chemoresistant Acute Myeloid Leukemia

Advanced Healthcare Materials, EarlyView.
We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He, Lingxiao Zhang, Yue Xiong, Yu Wang, Yuqing Zeng, Dandan Su, Ran Wang, Ying Li, Hongbo Chen, Fang Cheng, Zhi Ping Xu   +10 more
wiley   +1 more source

Reproducibility of preclinical animal research improves with heterogeneity of study samples

, 2018
Bernhard Voelkl, Lucile Vogt, Emily S. Sena, Hanno Würbel   +3 more
openalex   +2 more sources

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Ferroptosis in diabetes mellitus and its complications: overview of clinical and preclinical research. [PDF]

Cell Death Discov
Li X, Fang M, Liu X, Jiang J, Wang S, Mao X, Zou Z, Jin W.   +7 more
europepmc   +1 more source

A Personalized, 3D Printed Polymeric Device for the Prevention of Post‐Myocardial Infarction Cardiac Remodeling

Advanced Healthcare Materials, EarlyView.
Myocardial infarction often leads to pathological remodelling and ventricular dilatation, key features of HFrEF. This study introduces a personalized, 3D‐printed cardiac restraint device (CARD) printed using rationally designed inks displaying the requested printability and mechanical properties.
Nicola Mansour, Daniel Cohn, Ishita Sarkar, Raja Alamore, Kareem Abd Rbo, Offer Amir, Dean Nachman   +6 more
wiley   +1 more source

Development of a non-human primate model for preclinical research of a novel auditory nerve implant. [PDF]

Front Neurosci
Sondh I, Johnson LA, Ghose GM, Loveland A, Larson L, Lim HH, Adams ME.   +6 more
europepmc   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Biological Sex Is Under-Reported in Cartilage-Related Preclinical Research: A Cross-Sectional Analysis. [PDF]

JOR Spine
Zuncheddu D, Buedo P, Stoddart MJ, Creemers LB, Grad S, Waligora M.   +5 more
europepmc   +1 more source