Results 91 to 100 of about 808,538 (334)

A Narrative Review of Preclinical In Vitro Studies Investigating microRNAs in Myocarditis

Current Issues in Molecular Biology
According to the World Health Organization’s statement, myocarditis is an inflammatory myocardium disease. Although an endometrial biopsy remains the diagnostic gold standard, it is an invasive procedure, and thus, cardiac magnetic resonance imaging has ...
Olga Grodzka, Grzegorz Procyk, Małgorzata Wrzosek   +2 more
doaj   +1 more source

Ibandronate: Pharmacology and preclinical studies

Bone, 2006
Over the past three decades, changes to the chemical structures of the bisphosphonates have resulted in progressive improvements in their antiresorptive potencies. Ibandronate is a potent, nitrogen-containing bisphosphonate that possesses a tertiary nitrogen group on its R2 side chain and a hydroxyl group on its R1 side chain, which together confer one
openaire   +2 more sources

Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries [PDF]

, 2011
<p><b>Objective:</b> We have previously demonstrated that bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs), is effective in reducing neointimal formation in rodent models of vascular injury by reducing smooth ...
Baker, A.H., Biondi, G., Colombo, A., Di Lauro, M.V., Gordon, P., Grassia, G., Guglielmotti, A., Ialenti, A., Kennedy, S., Maddaluno, M., Maffia, P.   +10 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Ethical implications of preclinical studies

Регуляторные исследования и экспертиза лекарственных средств, 2018
Animal experiments are fundamental for the biomedical science. The development of new drugs is always associated with a large number of preclinical experiments in animals.
I. N. Tyurenkov, E. M. Lomkina, D. V. Kurkin, D. A. Bakulin, E. V. Volotova   +4 more
doaj  

Seroprevalence of Brucella spp. and Rift Valley fever virus infections in communal pastoral cattle at the wildlife-livestock interface, Zambezi region, Namibia

Frontiers in Veterinary Science
IntroductionBrucellosis and Rift Valley fever (RVF) are neglected zoonotic diseases (NZD) that threaten public health, animal health, and production in resource-limited countries including Namibia.MethodsThe objective of this cross-sectional study was to
Oscar Madzingira, Hannah Munzel, Nicky Mowa Simasiku, Leo Tileni Lucas, Evelyn Nanjeke Mwenda, Simbarashe Chinyoka, Georgina Tjipura-Zaire, Frieda Shilongo, Christian Borgemeister, Siegfried Khaiseb, Simbarashe Chitanga, Sandra Junglen   +11 more
doaj   +1 more source

In vivo E2F reporting reveals efficacious schedules of MEK1/2–CDK4/6 targeting and mTOR–s6 resistance mechanisms [PDF]

, 2018
Targeting cyclin-dependent kinases 4/6 (CDK4/6) represents a therapeutic option in combination with BRAF inhibitor and/or MEK inhibitor (MEKi) in melanoma; however, continuous dosing elicits toxicities in patients. Using quantitative and temporal in vivo
Aplin, Andrew E., Cheng, Phil F., Chervoneva, Inna, Davies, Michael A., Dummer, Reinhard, Ertel, Adam, Fortina, Paolo, Hookim, Kim, Kleiber, Ines, Kwong, Lawrence N., Levesque, Mitch P., Nikbakht, Neda, Patel, Prem, Purwin, Timothy J., Teh, Jessica L. F.   +14 more
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

AMT: preclinical pharmacology studies.

International journal of oncology, 2009
Auron-Misheil-Therapy (AMT) consisting of aqueous camomile extract supplemented with calcium, vitamins, the antihistamine chlorpheniramine and human insulin is under development as anti-cancer treatment. AMT was preclinically investigated in tumour cell lines and tumour xenografts to guide clinical phase I/II studies.
Faiz, Niazi, Joachim, Drevs, Klaus, Diergarten, Annette, Dorn, Armin, Maier, Heinz Herbert, Fiebig, Eddy, Bruyns, Jürgen, Scheele   +7 more
openaire   +5 more sources

Epidemiology of wild animal rabies in Namibia from 2001 to 2019: implications for controlling the infection in domestic animals

BMC Veterinary Research
Background Rabies is an acute, fatal zoonosis of mammals that is endemic in Namibia. Wild animals have been implicated as reservoirs of the infection around the world.
Oscar Madzingira, Emmanuel Hikufe Hikufe, Charles Byaruhanga, Michael Sinvula Lukubwe, Simbarashe Chinyoka, Evelyn Nanjeke Mwenda, Esther Mariana Muradzikwa   +6 more
doaj   +1 more source