Results 71 to 80 of about 13,502,816 (309)
In Vitro and In Vivo Effects of a Copper(II)-Hydrazone Complex Against Human Osteosarcoma
PharmaceuticsIntroduction: Osteosarcoma (OS) is the most common primary malignant bone tumor in children and young adults, with poor prognosis due to relapse, metastasis, and chemoresistance.
Lucía Santa Maria de la Parra +7 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
BiomimeticsRadiation-induced skin injury (RISI) is one of the most common complications of radiotherapy, severely compromising patients’ quality of life. However, no standardized treatment has yet been established.
Yinhui Wang +7 more
doaj +1 more source
Stem Cells International, 2017 The use of spinal fusion procedures has rapidly augmented over the last decades and although autogenous bone graft is the “gold standard” for these procedures, alternatives to its use have been investigated over many years.
F. Salamanna +6 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Регуляторные исследования и экспертиза лекарственных средств, 2019 Chronic toxicity studies are an integral part of the overall toxicological evaluation of drug candidates. Biochemical studies of blood and urine serve to describe the general picture of the animal’s condition and to trace the dynamics of laboratory ...
A. V. Sorokina +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
ESTIMATION OF TOXIC EFFECTS OF MEDICINAL PREPARATION OF CABAZITAXEL
Разработка и регистрация лекарственных средств, 2019 A study of the toxic properties of the drug cabazitaxel was carried out on outbred rats with intravenous administration. The toxicity was assessed with a single and repeated weekly administration of the drug.
O. I. Avdeeva +5 more
doaj
Cancer Pathogenesis and TherapyMethionine restriction (MR) has shown significant promise in cancer therapy because it targets the unique methionine dependency of many tumors. However, despite extensive research on MR, a clear synthesis of preclinical findings and their translation ...
Nagaraju Bandaru +5 more
doaj +1 more source
Esketamine Cognition: SR and MA of Preclinical and Clinical Studies
Systematic Review and Meta-analysis of Esketamine cognitive enhancing effects from preclinical and clinical ...
Pamela Bagley +6 more
core +1 more source