Results 91 to 100 of about 601,377 (310)

Methionine restriction for cancer therapy: A comprehensive review of mechanisms and clinical applications

Cancer Pathogenesis and Therapy
Methionine restriction (MR) has shown significant promise in cancer therapy because it targets the unique methionine dependency of many tumors. However, despite extensive research on MR, a clear synthesis of preclinical findings and their translation ...
Nagaraju Bandaru, Shaik Mohammad Noor, Maha Lakshmi Kammili, Mohan Gandhi Bonthu, Alluri Pavani Gayatri, Perli Kranti Kumar   +5 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A Narrative Review of Preclinical In Vitro Studies Investigating microRNAs in Myocarditis

Current Issues in Molecular Biology
According to the World Health Organization’s statement, myocarditis is an inflammatory myocardium disease. Although an endometrial biopsy remains the diagnostic gold standard, it is an invasive procedure, and thus, cardiac magnetic resonance imaging has ...
Olga Grodzka, Grzegorz Procyk, Małgorzata Wrzosek   +2 more
doaj   +1 more source

Drugs under preclinical and clinical study for treatment of acute and chronic lymphoblastic leukemia [PDF]

, 2016
Joe Antony Jacob, Jumah Masoud Mohammad Salmani, Baoan Chen Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, People’s Republic of China Abstract: Targeted therapy has modernized the ...
Jacob JA, Salmani JMM, Chen B
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Seroprevalence of Brucella spp. and Rift Valley fever virus infections in communal pastoral cattle at the wildlife-livestock interface, Zambezi region, Namibia

Frontiers in Veterinary Science
IntroductionBrucellosis and Rift Valley fever (RVF) are neglected zoonotic diseases (NZD) that threaten public health, animal health, and production in resource-limited countries including Namibia.MethodsThe objective of this cross-sectional study was to
Oscar Madzingira, Hannah Munzel, Nicky Mowa Simasiku, Leo Tileni Lucas, Evelyn Nanjeke Mwenda, Simbarashe Chinyoka, Georgina Tjipura-Zaire, Frieda Shilongo, Christian Borgemeister, Siegfried Khaiseb, Simbarashe Chitanga, Sandra Junglen   +11 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies [PDF]

, 2017
Among the LDL receptor (LDLR) family members, the roles of LDLR-related protein (LRP)1 in the pathogenesis of Alzheimer's disease (AD), especially late-onset AD, have been the most studied by genetic, neuropathological, and biomarker analyses (clinical ...
Tachibana, Masaya, Kanekiyo, Takahisa, Shinohara, Mitsuru, Bu, Guojun, Masaya Tachibana, Guojun Bu, Takahisa Kanekiyo, Mitsuru Shinohara   +7 more
core   +1 more source

Epidemiology of wild animal rabies in Namibia from 2001 to 2019: implications for controlling the infection in domestic animals

BMC Veterinary Research
Background Rabies is an acute, fatal zoonosis of mammals that is endemic in Namibia. Wild animals have been implicated as reservoirs of the infection around the world.
Oscar Madzingira, Emmanuel Hikufe Hikufe, Charles Byaruhanga, Michael Sinvula Lukubwe, Simbarashe Chinyoka, Evelyn Nanjeke Mwenda, Esther Mariana Muradzikwa   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source