Results 91 to 100 of about 13,502,816 (309)

Epidemiology of wild animal rabies in Namibia from 2001 to 2019: implications for controlling the infection in domestic animals

BMC Veterinary Research
Background Rabies is an acute, fatal zoonosis of mammals that is endemic in Namibia. Wild animals have been implicated as reservoirs of the infection around the world.
Oscar Madzingira, Emmanuel Hikufe Hikufe, Charles Byaruhanga, Michael Sinvula Lukubwe, Simbarashe Chinyoka, Evelyn Nanjeke Mwenda, Esther Mariana Muradzikwa   +6 more
doaj   +1 more source

Seroprevalence of Brucella spp. and Rift Valley fever virus infections in communal pastoral cattle at the wildlife-livestock interface, Zambezi region, Namibia

Frontiers in Veterinary Science
IntroductionBrucellosis and Rift Valley fever (RVF) are neglected zoonotic diseases (NZD) that threaten public health, animal health, and production in resource-limited countries including Namibia.MethodsThe objective of this cross-sectional study was to
Oscar Madzingira, Hannah Munzel, Nicky Mowa Simasiku, Leo Tileni Lucas, Evelyn Nanjeke Mwenda, Simbarashe Chinyoka, Georgina Tjipura-Zaire, Frieda Shilongo, Christian Borgemeister, Siegfried Khaiseb, Simbarashe Chitanga, Sandra Junglen   +11 more
doaj   +1 more source

The non-reconstructive treatment of complete ACL tear with biological enhancement in clinical and preclinical studies: A systematic review

, 2018
Introduction: There is still controversy regarding the bio-enhanced non-reconstructive ACL treatment. Materials and methods: A search for articles in databases was performed in February 2017.
Shu-Hang Yung, Yau Chuk Cheuk, Yue Li, Sai Cheun Fu, Guanyang Song, Hua Feng   +5 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Evaluation of Published Preclinical Experimental Studies in Medicine: Methodology Issues

, 2019
© 2019 Slobodan M. Jankovic, Belma Kapo, Aziz Sukalo, Izet Masic. Introduction: Inappropriate design of experimental studies in medicine inevitably leads to inaccurate or false results, which serve as basis for erroneous and biased conclusions.
Kapo B., Masic, Izet, Jankovic, Slobodan, Sukalo A.   +3 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Systematic Review of Preclinical Studies on Schizonepeta tenuifolia Sole Extract

To explore the mechanisms of action of Schizonepeta tenuifolia when administered through non-oral routes, a systematic review of preclinical studies was conducted, divided into in vivo and in vitro ...
Hongmin Chu
core   +1 more source