Results 91 to 100 of about 814,690 (301)

A Narrative Review of Preclinical In Vitro Studies Investigating microRNAs in Myocarditis

Current Issues in Molecular Biology
According to the World Health Organization’s statement, myocarditis is an inflammatory myocardium disease. Although an endometrial biopsy remains the diagnostic gold standard, it is an invasive procedure, and thus, cardiac magnetic resonance imaging has ...
Olga Grodzka, Grzegorz Procyk, Małgorzata Wrzosek   +2 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

AMT: preclinical pharmacology studies.

International journal of oncology, 2009
Auron-Misheil-Therapy (AMT) consisting of aqueous camomile extract supplemented with calcium, vitamins, the antihistamine chlorpheniramine and human insulin is under development as anti-cancer treatment. AMT was preclinically investigated in tumour cell lines and tumour xenografts to guide clinical phase I/II studies.
Faiz, Niazi, Joachim, Drevs, Klaus, Diergarten, Annette, Dorn, Armin, Maier, Heinz Herbert, Fiebig, Eddy, Bruyns, Jürgen, Scheele   +7 more
openaire   +5 more sources

Seroprevalence of Brucella spp. and Rift Valley fever virus infections in communal pastoral cattle at the wildlife-livestock interface, Zambezi region, Namibia

Frontiers in Veterinary Science
IntroductionBrucellosis and Rift Valley fever (RVF) are neglected zoonotic diseases (NZD) that threaten public health, animal health, and production in resource-limited countries including Namibia.MethodsThe objective of this cross-sectional study was to
Oscar Madzingira, Hannah Munzel, Nicky Mowa Simasiku, Leo Tileni Lucas, Evelyn Nanjeke Mwenda, Simbarashe Chinyoka, Georgina Tjipura-Zaire, Frieda Shilongo, Christian Borgemeister, Siegfried Khaiseb, Simbarashe Chitanga, Sandra Junglen   +11 more
doaj   +1 more source

Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer. [PDF]

, 2014
Preventing breast cancer is an effective strategy for reducing breast cancer deaths. The purpose of chemoprevention (also termed preventive therapy) is to reduce cancer incidence by use of natural, synthetic, or biological agents.
Brown, Powel H, Litzenburger, Beate C
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Epidemiology of wild animal rabies in Namibia from 2001 to 2019: implications for controlling the infection in domestic animals

BMC Veterinary Research
Background Rabies is an acute, fatal zoonosis of mammals that is endemic in Namibia. Wild animals have been implicated as reservoirs of the infection around the world.
Oscar Madzingira, Emmanuel Hikufe Hikufe, Charles Byaruhanga, Michael Sinvula Lukubwe, Simbarashe Chinyoka, Evelyn Nanjeke Mwenda, Esther Mariana Muradzikwa   +6 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

ESTIMATION OF TOXIC EFFECTS OF MEDICINAL PREPARATION OF CABAZITAXEL

Разработка и регистрация лекарственных средств, 2019
A study of the toxic properties of the drug cabazitaxel was carried out on outbred rats with intravenous administration. The toxicity was assessed with a single and repeated weekly administration of the drug.
O. I. Avdeeva, E. V. Shekunova, A. A. Muzhikyan, M. N. Makarova, V. G. Makarov, A. Ya. Hymenov   +5 more
doaj  

L-Tetrahydropalamatine: A Potential New Medication for the Treatment of Cocaine Addiction [PDF]

, 2012
Levo-tetrahydropalmatine (l-THP) is an active constituent of herbal preparations containing plant species of the genera Stephania and Corydalis and has been approved and used in China for a number of clinical indications under the drug name Rotundine ...
Mantsch, John R., Wang​, Jia Bei
core   +1 more source