Results 101 to 110 of about 808,538 (334)

Generalized data of criteria of risk factors for the use of the drug torasemide from the materials of its preclinical studies [PDF]

, 2020
Н. А. Анисимова, Natalia O. Selizarova, Г. А. Плиско, E. D. Semivelichenko, Svetlana M. Napalkova   +4 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

CSF sTREM2: Marking the tipping point between preclinical AD and dementia? [PDF]

, 2016
Biomarkers for Alzheimer's disease (AD) have improved our understanding of the temporal sequence of biological events that lead to AD dementia (Jack et al, 2013).
Holtzman, David M, Schindler, Suzanne E
core   +2 more sources

Perinatal Gene Transfer to the Liver [PDF]

, 2011
The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within
Buckley, SM, Chan, JK, Howe, SJ, McKay, TR, Rahim, AA, Waddington, SN, Ward, NJ   +6 more
core   +1 more source

Emvolio - A battery operated portable refrigerator preserves biochemical and haematological integrity of biological samples in preclinical studies [PDF]

, 2022
Swastika Maity, Jaya Aakriti, Suman Manandhar, Sharad B Anchan, Ashlesh Bhat, Mayur U Shetty, Yogendra Nayak   +6 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

ESTIMATION OF TOXIC EFFECTS OF MEDICINAL PREPARATION OF CABAZITAXEL

Разработка и регистрация лекарственных средств, 2019
A study of the toxic properties of the drug cabazitaxel was carried out on outbred rats with intravenous administration. The toxicity was assessed with a single and repeated weekly administration of the drug.
O. I. Avdeeva, E. V. Shekunova, A. A. Muzhikyan, M. N. Makarova, V. G. Makarov, A. Ya. Hymenov   +5 more
doaj  

Guidelines for the recording and evaluation of pharmaco-EEG data in man: the International Pharmaco-EEG Society (IPEG) [PDF]

, 2012
The International Pharmaco-EEG Society (IPEG) presents updated guidelines summarising the requirements for the recording and computerised evaluation of pharmaco-EEG data in man.
BABILONI, CLAUDIO, Boeijinga PH, Brunovsky M, Drinkenburg WH, Ffytche DH, Freeman J, Hegerl U, Hirata K, IPEG Pharmaco EEG Guidelines C.o.m.m.i.t.t.e.e. Collaborators, Jobert M, Kinoshita T, Knott VJ, Lopes Da Silva FH, Matousek M, Mucci A, Nottage JF, Olbrich S, Prichep LS, Ruigt GS, Saletu B, Stancak A, Strik WK, van Gerven JM, Wilson FJ, Wise RG   +24 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

ANALYTICAL REVIEW OF THE NORMATIVE BASE TO PROVIDE THE GOOD QUALITY OF PRECLINICAL STUDIES IN RUSSIA

Разработка и регистрация лекарственных средств, 2019
The main goal of preclinical studiesis the development of effective, high-quality and safe drugs. The task of preclinical studiesis to obtain exhaustive information, reliable and reproducible results.
A. I. Selezneva, S. V. Glembotsky, S. V. Polyakov, M. N. Makarova, V. G. Makarov, A. A. Churin   +5 more
doaj