Results 151 to 160 of about 808,538 (334)

Preclinical Study [PDF]

, 2020
openaire   +1 more source

In vitrostudy of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study

, 2019
Nafisa Gull, Shahzad Maqsood Khan, Muhammad Taqi Zahid Butt, Syed Khalid, Muhammad Shafiq, Atif Islam, Sumreen Asim, Sadaf Hafeez, Rafi Ullah Khan   +8 more
openalex   +2 more sources

Supplementary Figure from Preclinical and Pilot Study of Type I FLT3 Tyrosine Kinase Inhibitor, Crenolanib, with Sorafenib in Acute Myeloid Leukemia and <i>FLT3</i>-Internal Tandem Duplication

, 2023
Hiroto Inaba, Jolieke G. van Oosterwijk, John C. Panetta, Lie Li, Daelynn R. Buelow, James S. Blachly, Sheila Shurtleff, Ching‐Hon Pui, Raul C. Ribeiro, Jeffrey E. Rubnitz, Stanley Pounds, Sharyn D. Baker   +11 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Data from Preclinical Mammalian Safety Studies of EPHARNA (DOPC Nanoliposomal EphA2-Targeted siRNA)

, 2023
Michael J. Wagner, Rahul Mitra, Mark J. McArthur, Wallace B. Baze, Kirstin Barnhart, Sherry Y. Wu, Cristian Rodriguez-Aguayo, Xinna Zhang, Robert L. Coleman, Gabriel Lopez‐Berestein, Anil K. Sood   +10 more
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Design Features of Nonclinical Studies of In Vivo Gene Therapy Medicinal Products. Part 1: Pharmacological studies

Инновационная медицина Кубани
The article focuses on the specific aspects of nonclinical studies (NCS) and the cunduct of pharmacological investigations of in vivo gene therapy medicinal products (GTMPs) which involve the administration of vectors with recombinant nucleic acids into ...
O. A. Rachinskaya, E. V. Melnikova, V. A. Merkulov   +2 more
doaj   +1 more source

Table S1 from Novel Thienoduocarmycin–Trastuzumab ADC Demonstrates Strong Antitumor Efficacy with Favorable Safety Profile in Preclinical Studies

, 2023
Barbara Valsasina, Paolo Orsini, Michele Caruso, Clara Albanese, Antonella Ciavolella, Ulisse Cucchi, Ivan Fraietta, Nicola Melillo, Francesco Fiorentini, Simona Rizzi, Matteo Salsa, Antonella Isacchi, Fabio Gasparri   +12 more
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Preclinical Studies in Vascularized Composite Allotransplantation

Plastic and Reconstructive Surgery, Global Open, 2023
Andreea Grosu-Bularda, Dragos Zamfirescu, Florin-Vlad Hodea, Alexandru Stoian, Luana Lazarescu, Razvan Nicolae Teodoreanu, Ioan Lascar   +6 more
doaj   +1 more source