Results 231 to 240 of about 814,690 (301)

Advances in chimeric antigen receptor-natural killer cell therapy: from mechanisms and preclinical studies to clinical application. [PDF]

Front Oncol
Ren T, Wang F, Liu X, Guo J, Xie S.
europepmc   +1 more source

A Superhydrophobic 3D Cell Culture System Reveals the Mechanobiological Role of Cancer‐Associated Fibroblasts in Prostate Cancer Metastasis

Advanced Healthcare Materials, EarlyView.
A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter, Abigail R. Fabiano, Ehsan Aalaei, Jason Deng, Dakota E. Rostant, Michael R. King   +5 more
wiley   +1 more source

Repurposing memantine as an oral therapy for visceral leishmaniasis: identification of direct leishmanicidal activity and immune system modulation in preclinical studies. [PDF]

Front Pharmacol
Gonçalves-Ozório G, Capilla LG, Emiliano YSS, Gervazoni LFO, De Luca PM, Almeida-Amaral EE.   +5 more
europepmc   +1 more source

A Physiological Microfluidic Blood–Brain‐Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation

Advanced Healthcare Materials, EarlyView.
A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen, Neona M. Lowe, Sophia Kellogg, Kuan‐Wei Huang, Hannah O'Toole, Elizabeth J. Hale, Venktesh S. Shirure, Bhupinder S. Shergill, Steven C. George, Randy P. Carney   +9 more
wiley   +1 more source

Herbal Interventions in Parkinson's Disease: A Systematic Review of Preclinical Studies. [PDF]

Cell Mol Neurobiol
Zhao W, Cui H, Liu J, Sun H, Zhang Z, Zhang Z, Ma D.   +6 more
europepmc   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Natural and Synthetic Compounds Against Colorectal Cancer: An Update of Preclinical Studies in Saudi Arabia. [PDF]

Curr Oncol
Vaali-Mohammed MA, Nazar A, Meeramaideen M, Khan S.   +3 more
europepmc   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Analysis of the Outcomes Studied in the Application of Invasive and Non-Invasive Vagus Nerve Stimulation in Clinical and Preclinical Studies Involving Stroke-A Scoping Review. [PDF]

NeuroSci
Zambetta ML, Prati JM, de Russo TL, Gianlorenço ACL.   +3 more
europepmc   +1 more source

Phase-Specific Evaluation of Sciatic Nerve Regeneration in Preclinical Studies: A Review of Functional Assessment, Emerging Therapies, and Translational Value. [PDF]

Int J Mol Sci
Viezuină DM, Burlacu IM, Greșiță A, Matache IM, Târtea EA, Mușat MI, Amzoiu MO, Cătălin B, Sfredel V, Mitran SI.   +9 more
europepmc   +1 more source