Results 161 to 170 of about 781,590 (289)

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

Brain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová, Lucie Pfeiferová, Tadeáš Karel Smetana, Petr Výmola, Nikola Ternerová, Michal Zubaľ, Michal Kolář, Jana Šáchová, Soňa Gyönyörová, Eva Balážiová, Magdalena Houdová Megová, Jakub Červenka, Helena Kupcová Skalníková, Michal Španko, Karel Smetana Jr., Lukáš Lacina, David Netuka, Robert Tomáš, Petr Bušek, Aleksi Šedo   +19 more
wiley   +1 more source

Fast Numerical Solvers for Parameter Identification Problems in Mathematical Biology. [PDF]

J Sci Comput
Benková K, Pearson JW, Ptashnyk M.
europepmc   +1 more source

An Evaluation of Multiprocessor Support for Fine-grain Synchronization in Preconditioned Conjugate Gradient

, 1993
This thesis explores the use of fine-grain synchronization in the preconditioned conjugate gradient (PCG) method using the modified incomplete Cholesky factorization of the coefficient matrix as a ...
Yeung, Donald
core  

Adiponectin promotes AMPA receptor trafficking and enhances excitatory synaptic transmission at hippocampal synapses via AMP‐activated protein kinase signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Peripherally derived adiponectin crosses the blood–brain barrier and targets severa0l brain regions. Adiponectin receptors are highly expressed in the hippocampus, and play a pro‐cognitive role as adiponectin markedly influences the functioning of hippocampal synapses.
Alexandra Soca, Patricia Raposo Afonso, Valentin Morfin, James Cantley, Jenni Harvey   +4 more
wiley   +1 more source

Upregulated PKM2 Protects Dopaminergic Neurons From Oxidative Damage Through Nrf2 Transactivation in an MPTP-Induced Mouse Model of Parkinson's Disease. [PDF]

CNS Neurosci Ther
Mei M, Miao QQ, Li MK, Wang HR, Ding JH, Hu G, Wei Y.   +6 more
europepmc   +1 more source

Preconditioned conjugate gradient methods with sufficient descent condition for large-scale unconstrained optimization

, 2018
In this paper, we propose preconditioned conjugate gradient method by applying preconditioning technique to the search direction. Besides, we also enforce the search direction to satisfy sufficient descent and boundedness condition.
Muhammad Nizammul Hayad Bin Yahya
core  

Computing Skinning Weights via Convex Duality

Computer Graphics Forum, EarlyView.
We present an alternate optimization method to compute bounded biharmonic skinning weights. Our method relies on a dual formulation, which can be optimized with a nonnegative linear least squares setup. Abstract We study the problem of optimising for skinning weights through the lens of convex duality.
J. Solomon, O. Stein
wiley   +1 more source

Deep Learning-Based 3D Gravity Inversion with Well-Logging Prior Information. [PDF]

Sensors (Basel)
Cai MT, Zhang YJ, Jiang AF, He L.
europepmc   +1 more source

Hierarchical Differentiable Fluid Simulation

Computer Graphics Forum, EarlyView.
We introduce a two‐step algorithm that significantly reduces memory usage for solving control problems using differentiable fluid simulation techniques: our method first optimizes for bulk forces at reduced resolution, then refines local details over sub‐domains while maintaining differentiability. In trading runtime for memory, it enables optimization
Xiangyu Kong, Arnaud Schoentgen, Damien Rioux‐Lavoie, Paul G. Kry, Derek Nowrouzezahrai   +4 more
wiley   +1 more source

A 3D inversion method of TEM combining PSO-NLCG optimization and adaptive regularization. [PDF]

Sci Rep
Jianqiang C, Feng Z, Xuhai D, Yong'en L, Yanhai Z, Yunfei H, Jun Z, Yongbang Y, Gongbin Y, Xin H.   +9 more
europepmc   +1 more source