Results 101 to 110 of about 12,114 (185)

Approved CAR T cell therapies [PDF]

, 2018
Two autologous chimeric antigen receptor (CAR) T cell therapies (Kymriah™ and Yescarta™) were recently approved by the FDA. Kymriah™ is for the treatment of pediatric patients and young adults with refractory or relapse (R/R) B cell precursor acute ...
Kros, J.M. (Johan), Li, J. (Jin), Zheng, P.P. (Pingpin)   +2 more
core   +4 more sources

Haploidentical CD7 CAR T-cells induced remission in a patient with TP53 mutated relapsed and refractory early T-cell precursor lymphoblastic leukemia/lymphoma [PDF]

, 2022
Haiping Dai, Wei Cui, Qingya Cui, Wenjuan Zhu, Huimin Meng, Min-qing Zhu, Xiaming Zhu, Lin Yang, Depei Wu, Xiaowen Tang   +9 more
openalex   +1 more source

Precursor T-Cell Acute Lymphoblastic Leukemia/ Lymphoblastic Lymphoma and Acute Biphenotypic Leukemias [PDF]

, 2007
Xin Han, Carlos E. Bueso‐Ramos
openalex   +2 more sources

ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype [PDF]

, 2017
Fusion genes involving ZNF384 have recently been identified in B-cell precursor acute lymphoblastic leukemia, and 7 fusion partners have been reported. We further characterized this type of fusion gene by whole transcriptome sequencing and/or polymerase ...
Fujimura Junya, Fukushima Takashi, Hata Kenichiro, Hino Moeko, Hirabayashi Shinsuke, Ichikawa Hitoshi, Kajiwara Ryosuke, Kakuda Harumi, Kato Keisuke, Kato Motohiro, Kinoshita Akitoshi, Kiyokawa Nobutaka, Koh Katsuyoshi, Kubo Michiaki, Kurosawa Hidemitsu, Manabe Atsushi, Matsubara Yoichi, Matsuda Koich, Matsumoto Kenji, Momozawa Yukihide, Morimoto Tsuyoshi, Moriwaki Koichi, Nakabayashi Kazuhiko, Nakamura Kozue, Noguchi Yasushi, Ogata-Kawata Hiroko, Ohara Akira, Ohki Kentaro, Okamura Kohji, Osumi Tomoo, Saito Yuya, Sakamoto Hiromi, Sakashita Kazuo, Takita Junko, Terada Kazuki, Yaguchi Akinori, Yoshida Teruhiko, Yoshimi Ai, Yuza Yuki, 福島 敬   +39 more
core   +1 more source

A Novel Case of Indolent T‐Lymphoblastic Proliferation in Metastatic High‐Grade Serous Adenocarcinoma

International Journal of Laboratory Hematology, EarlyView.
Mia Dahl Sørensen, Anja Ør Knudsen, Michael Boe Møller   +2 more
wiley   +1 more source

Immune Surveillance and Immune Escape in Cancer: Mechanisms and Immunotherapy

MedComm, Volume 6, Issue 10, October 2025.
Our review focused on how specific cellular subsets crucial for igniting tumor immunity cycle, notably effector and helper T cells alongside antigen presentation cells, interact closely in both antigen‐dependent and ‐independent manners (within centered ring) adjacent to cancer cells.
Ying Peng, Linsheng Zhan, Jianxiang Shi, Jie Wang, Yueying Li, Xiangdong Sun, Jie Lv, Huiyu Yang, Zan Qiu, Xingzhao Liu, Chenyan Li, Shanshan Gong, Wen Jia, Huiying Wang, Yuqi Zhao, Bin Zhang, Wei Guo, Jiancheng Guo, Jian Shang, Qianqian Zhou, Yanan Yang, Feng Gao   +21 more
wiley   +1 more source

Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. [PDF]

, 2015
TCF3-HLF-positive acute lymphoblastic leukemia (ALL) is currently incurable. Using an integrated approach, we uncovered distinct mutation, gene expression and drug response profiles in TCF3-HLF-positive and treatment-responsive TCF3-PBX1-positive ALL. We
Amstislavskiy, V., Badarinarayan, N., Bartram, T., Baruchel, A., Basso, G., Borkhardt, A., Bornhauser, B., Bourquin, J.P., Canpolat, C., Cario, G., Cavé, H., Dakaj, D., Delorenzi, M., Dobay, M.P., Eckert, C., Ellinghaus, E., Eugster, S., Fischer, U., Forster, M., Franke, A., Frismantas, V., Ginzel, S., Gombert, M., Haas, O.A., Heidenreich, O., Hemmrich-Stanisak, G., Hezaveh, K., Hornhardt, S., Husemann, P., Höll, J.I., Kachroo, P., Korbel, J.O., Kratsch, C., Kratz, C.P., Kronnie, G.T., Lehrach, H., Marovca, B., McHardy, A.C., Moorman, A.V., Niggli, F., Panzer-Grümayer, R., Petersen, B.S., Raeder, B., Ralser, M., Rinaldi, A., Risch, T., Rosenstiel, P., Schrappe, M., Schreiber, S., Schäfer, D., Schütte, M., Stade, B., Stanulla, M., Stütz, A.M., Sultan, M., Sungalee, S., Tchinda, J., Thiele, R., Vora, A., Warnatz, H.J., Weid, N.v., Worth, C.L., Yaspo, M.L., Zaliova, M., Zhang, L., Zichner, T., Zimmermann, M.   +66 more
core   +1 more source

Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 10, October 2025.
This review comprehensively examines the regulatory mechanisms and physiological roles of guanine nucleotide exchange factors (GEFs) and their small GTPase substrates, highlighting their significance in cellular processes and disease pathogenesis.
Zexing Lin, Chujun Ni, Haiyang Jiang, Huan Yang, Liting Deng, Peizhao Liu, Xuanheng Li, Yilong Yu, Weijie Li, Runnan Wang, Bo Liao, Jiaqi Kang, Juanhan Liu, Xiuwen Wu, Jianan Ren, Yun Zhao   +15 more
wiley   +1 more source

γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell Malignancies

Case Reports in Hematology, 2017
Gamma delta (γδ) T-cell antigen receptor (TCR) expression and its related T-cell differentiation are not commonly reported in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL).
Eric X. Wei, Vasiliki Leventaki, John K. Choi, Susana C. Raimondi, Elizabeth M. Azzato, Sheila A. Shurtleff, Menchu G. Ong, Diana M. Veillon, James D. Cotelingam, Rodney E. Shackelford   +9 more
doaj   +1 more source

Design Strategies for Novel Lipid Nanoparticle for mRNA Vaccine and Therapeutics: Current Understandings and Future Perspectives

MedComm, Volume 6, Issue 10, October 2025.
This review summarizes strategies to optimize lipid nanoparticles (LNPs) for improved targeting, endosomal escape, and safety. It highlights mRNA design, alternative delivery systems, and recent therapeutic advances across infectious diseases, cancer, and drug applications.
Xiaochi Li, Junli Li, Jiazheng Wei, Weixin Du, Cheng Su, Xiaobin Shen, Aihua Zhao, Miao Xu   +7 more
wiley   +1 more source