Results 121 to 130 of about 59,825 (253)

Molecular mechanisms in haematological malignancies [PDF]

, 2009
Haematopoiesis requires the constant production of large numbers of peripheral blood cells. This process is under tight control of transcription factor networks as well as cytokines, growth factors and hormones.
Avellino, Roberto, Grech, Godfrey, Schembri-Wismayer, Pierre   +2 more
core  

Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. [PDF]

, 2015
TCF3-HLF-positive acute lymphoblastic leukemia (ALL) is currently incurable. Using an integrated approach, we uncovered distinct mutation, gene expression and drug response profiles in TCF3-HLF-positive and treatment-responsive TCF3-PBX1-positive ALL. We
Amstislavskiy, V., Badarinarayan, N., Bartram, T., Baruchel, A., Basso, G., Borkhardt, A., Bornhauser, B., Bourquin, J.P., Canpolat, C., Cario, G., Cavé, H., Dakaj, D., Delorenzi, M., Dobay, M.P., Eckert, C., Ellinghaus, E., Eugster, S., Fischer, U., Forster, M., Franke, A., Frismantas, V., Ginzel, S., Gombert, M., Haas, O.A., Heidenreich, O., Hemmrich-Stanisak, G., Hezaveh, K., Hornhardt, S., Husemann, P., Höll, J.I., Kachroo, P., Korbel, J.O., Kratsch, C., Kratz, C.P., Kronnie, G.T., Lehrach, H., Marovca, B., McHardy, A.C., Moorman, A.V., Niggli, F., Panzer-Grümayer, R., Petersen, B.S., Raeder, B., Ralser, M., Rinaldi, A., Risch, T., Rosenstiel, P., Schrappe, M., Schreiber, S., Schäfer, D., Schütte, M., Stade, B., Stanulla, M., Stütz, A.M., Sultan, M., Sungalee, S., Tchinda, J., Thiele, R., Vora, A., Warnatz, H.J., Weid, N.v., Worth, C.L., Yaspo, M.L., Zaliova, M., Zhang, L., Zichner, T., Zimmermann, M.   +66 more
core   +1 more source

Synergism between the mTOR inhibitor rapamycin and FAK down-regulation in the treatment of acute lymphoblastic leukemia

Journal of Hematology & Oncology, 2016
Background Acute lymphoblastic leukemia (ALL) is an aggressive malignant disorder of lymphoid progenitor cells in both children and adults. Although improvements in contemporary therapy and development of new treatment strategies have led to dramatic ...
Pei-Jie Shi, Lu-Hong Xu, Kang-Yu Lin, Wen-jun Weng, Jian-Pei Fang   +4 more
doaj   +1 more source

High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-acute lymphoblastic leukemia [PDF]

, 2016
Table S4. Complete list of signaling pathways dysregulated in patients who achieved complete remission therapy. Signaling pathway analysis was done using MetaCore KPA using the set of 442 genes differentially expressed between good and poor response ...
Alba L. Combita, Claudia Cardozo, Jennifer Cudris, Jose Bareño, Jovanny Zabaleta, Juan S. Castillo, Julio Solano, Leonardo J. Enciso, Li Li, Maria V. Herrera, Nataly Cruz-Rodriguez, Olga C. Lozano, Paula L. Pinzon, Sandra M. Quijano   +13 more
core   +6 more sources

How I Treat Newly Diagnosed T-cell Acute Lymphoblastic Leukemia (T-ALL) and T-cell Lymphoblastic Lymphoma in Children.

Blood, 2019
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy that has historically been associated with a very poor prognosis. Nevertheless, despite a lack of incorporation of novel agents, the development of intensified T-ALL focused ...
D. Teachey, D. O’Connor
semanticscholar   +1 more source

Medical Imagery: Cytomegalovirus sialadenitis in a patient with B-cell acute lymphoblastic leukemia

IDCases
Cytomegalovirus (CMV) can cause a broad range of diseases, with severity depending on immune status, comorbidities, and age. Initial CMV infection usually occurs in childhood and is typically asymptomatic, leading to lifelong latency.
Javier A. Baena-Del Valle, Sergio D. Cruz-Romero, Martha L. Romero-Prieto, Adriana A. Flórez-Vargas, Diana M. Palacios-Ortiz, Guillermo E. Quintero-Vega, Mauricio A. Palau-Lázaro   +6 more
doaj   +1 more source

Rapid Progression of Mediastinal Tumor within a Few Days: A Case Report of T Cell Lymphoblastic Lymphoma

대한영상의학회지, 2016
T-cell lymphoblastic lymphoma is a highly aggressive tumor derived from lymphocyte of the thymus, which accounts for 2% of non-Hodgkin's lymphoma. The disease occurs most commonly in adolescent and young adult males.
Tae Ran Ahn, Young Kyung Lee, Hyun Jung Jun, Eun Ah Jung, Jin Sung Son   +4 more
doaj   +1 more source

Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus [PDF]

, 2016
Although there are high survival rates for children with acute lymphoblastic leukaemia, their outcome is often counterbalanced by the burden of toxic effects.
Attarbaschi, Andishe, Barzilai, Shlomit, Escherich, Gabriele, Frandsen, Thomas Leth, Halsey, Christina, Hough, Rachael, Jeha, Sima, Kato, Motohiro, Liang, Der-Cherng, Mikkelsen, Torben Stamm, Moricke, Anja, Niinimaki, Riitta, Piette, Caroline, Putti, Maria Caterina, Raetz, Elizabeth, Schmiegelow, Kjeld, Silverman, Lewis B., Skinner, Roderick, Tuckuviene, Ruta, van der Sluis, Inge, Zapotocka, Ester   +20 more
core   +2 more sources

Dysregulated RasGRP1 Responds to Cytokine Receptor Input in T Cell Leukemogenesis [PDF]

, 2012
Enhanced signaling by the small guanosine triphosphatase Ras is common in T cell acute lymphoblastic leukemia/lymphoma (T-ALL), but the underlying mechanisms are unclear. We identified the guanine nucleotide exchange factor RasGRP1 (Rasgrp1 in mice) as a
Ammon, Kristin, Bakker, Jeroen, Boeter, Anne, Chakraborty, Arup K., Coakley, Kristen, Dail, Monique, Govern, Christopher C., Hartzell, Catherine, Harvey, Richard C., Ksionda, Olga, Lemmens, Ed, Lenstra, Tineke L., Loh, Mignon, Roose, Jeroen P., Shannon, Kevin, Wabl, Matthias, Winter, Stuart S., Yang, Ming   +17 more
core   +1 more source

Pancreatitis in adult with acute lymphoblastic leukemia using L-asparaginase and simvastatin: case report and systematic review

Medicina, 2016
Context: Acute pancreatitis is a inflammatory process of the pancreas. It can be caused by gallstones, metabolic disorders, associated or not with alcohol abuse, or medication.
Renne Rodrigues, Diogo D. Gavarrete, Érika A. T. Bernardi, Eduardo C. Munhoz   +3 more
doaj   +1 more source