Results 51 to 60 of about 24,996 (206)

Adipocytes cause leukemia cell resistance to daunorubicin via oxidative stress response. [PDF]

, 2016
Adipocytes promote cancer progression and impair treatment, and have been shown to protect acute lymphoblastic leukemia (ALL) cells from chemotherapies. Here we investigate whether this protection is mediated by changes in oxidative stress.
Behan, James W, Heisterkamp, Nora, Ji, Lingyun, Mittelman, Steven D, Parmentier, Jean-Hugues, Sheng, Xia, Tucci, Jonathan   +6 more
core   +1 more source

The Clinical Characteristics and Prognosis of AYA and Older Adult ETP-ALL/LBL: A Real-World Multicenter Study in China

Frontiers in Oncology, 2022
Early T-cell precursor (ETP) lymphoblastic leukemia/lymphoma is a high-risk T lymphoblastic leukemia/lymphoma (T-ALL/LBL) subgroup. We performed a real-world multicenter study to explore the clinical characteristics and prognosis of adolescent and young ...
Jinyan Xiao, Zihong Cai, Hao Wang, Xuekai Li, Biqi Zhou, Yujie Liu, Ying Wang, Peipei Xu, Peipei Xu, Li Wang, Li Wang, Depei Wu, Liping Dou, Liping Dou, Hongsheng Zhou, Hongsheng Zhou, Yang Xu, Yang Xu   +17 more
doaj   +1 more source

Biological aspects of mTOR in leukemia [PDF]

, 2018
The mammalian target of rapamycin (mTOR) is a central processor of intra-and extracellular signals, regulating many fundamental cellular processes such as metabolism, growth, proliferation, and survival.
Bianchi, Mp, Gianfelici, V, Mirabilii, S, Piedimonte, M, Ricciardi, Mr, Tafuri, A.   +5 more
core   +1 more source

ABL oncogene amplification with p16^INK4a gene deletion in precursor T‐cell acute lymphoblastic leukemia/lymphoma: Report of the first case [PDF]

American Journal of Hematology, 2004
AbstractGene amplification is a relatively rare event in hematologic malignancies. The ABL gene on chromosome band 9q34 is a proto‐oncogene and is the well‐known translocation partner of the BCR gene on 22q11 giving rise to t(9;22)(q34;q11), which is the hallmark of chronic myeloid leukemia and is the most common chromosomal abnormality in adult acute ...
Hee-Jin, Kim, Hee-Yeon, Woo, Hong-Hoe, Koo, Eun-Young, Tak, Sun-Hee, Kim   +4 more
openaire   +2 more sources

Natural Killer Cell Lymphoblastic Leukemia/Lymphoma

Definitions, 2020
A provisional entity describing precursor lymphoid neoplasms that express CD56 and immature T-cell markers, lack B-lymphoid and myeloid markers, and have the immunoglobulin and T-cell receptor genes in the germline configuration.

semanticscholar   +1 more source

Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia [PDF]

, 2013
Purpose: Aberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) positive leukemias, activation of PI3K by dysregulated BCR-ABL tyrosine kinase ...
Badura, Susanne, Falkenburg, J. H. Frederik, Liebermann, Marcus, Nijmeijer, Bart A., Ottmann, Oliver Gerhard, Pfeifer, Heike, Ruthardt, Martin, Tesanovic, Tamara, Wystub, Sylvia   +8 more
core   +7 more sources

Non-Hodgkin Lymphoma in Children and Adolescents: Progress Through Effective Collaboration, Current Knowledge, and Challenges Ahead [PDF]

, 2015
Non-Hodgkin lymphoma is the fourth most common malignancy in children, has an even higher incidence in adolescents, and is primarily represented by only a few histologic subtypes. Dramatic progress has been achieved, with survival rates exceeding 80%, in
Auperin, Anne, Brugi\ue8res, Laurence, Burkhardt, Birgit, Cairo, Mitchell S, Damm Welk, Christine, Gross, Thomas G, Horibe, Keizo, Klapper, Wolfram, Lamant, Laurence, Le Deley, Marie C\ue9cile, Macintyre, Elizabeth, Minard Colin, V\ue9ronique, Mussolin, Lara, Patte, Catherine, Perkins, Sherrie L, Pillon, Marta, Poirel, H\ue9l\ue8ne A, Raphael, Martine, Reiter, Alfred, Rosolen, Angelo, Sandlund, John T, Williams, Denise, Woessmann, Wilhelm, Zimmerman, Martin   +23 more
core   +1 more source

DETECTION OF HEMATOPOIETIC NEOPLASMS IN CEREBROSPINAL FLUID BY IMMUNOPHENOTYPING: SINGLE-CENTER DATA ANALYSIS

Hematology, Transfusion and Cell Therapy, 2021
Introduction: Cerebrospinal fluid (CSF) infiltration can be identified at diagnosis and during the course of many hematopoietic malignancies, mainly acute leukemia and aggressive non-Hodgking lymphomas (NHL).
GF Bevilacqua, CM Bertolucci, AR Severino, RL Teotonio, M Penitenti, JE Conti-Spilari, MRV Ikoma-Colturato   +6 more
doaj   +1 more source

Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies [PDF]

, 2019
In cancer research, it remains challenging to functionally validate putative novel oncogenic drivers and to establish relevant preclinical models for evaluation of novel therapeutic strategies.
Berx, Geert, D'Hont, Jinke, Demoen, Lisa, Goossens, Steven, Haenebalcke, Lieven, Haigh, Jody J., Hochepied, Tino, Lammens, Tim, Lemeire, Kelly, Lintermans, Béatrice, Matthijssens, Filip, Pedro Pinto De Almeida, André, Pieters, Tim, Reunes, Lindy, T'Sas, Sara, Van Vlierberghe, Pieter, Vanrockeghem, Frédérique   +16 more
core   +2 more sources

Phosphoproteomic Analysis Reveals a Different Proteomic Profile in Pediatric Patients With T-Cell Lymphoblastic Lymphoma or T-Cell Acute Lymphoblastic Leukemia

Frontiers in Oncology, 2022
T-cell lymphoblastic lymphoma (T-LBL) and lymphoblastic leukemia (T-ALL) arise from the transformation of precursor T-cells sharing common morphological and immunophenotypic features.
Giulia Veltri, F. Lovisa, G. Cortese, M. Pillon, E. Carraro, S. Cesaro, M. Provenzi, S. Buffardi, S. Francescato, A. Biffi, B. Buldini, V. Conter, V. Serafin, L. Mussolin   +13 more
semanticscholar   +1 more source