Results 61 to 70 of about 5,396,547 (212)

Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment [PDF]

, 2009
Background: t(9;22) is a balanced translocation, and the chromosome 22 breakpoints (Philadelphia chromosome – Ph+) determine formation of different fusion genes that are associated with either Ph+ acute lymphatic leukemia (Ph+ ALL) or chronic myeloid ...
Xiaomin Zheng, Malcolm A S Moore, Martin Ruthardt, Ruthardt, Martin, Oancea, Claudia, Claudia Oancea, Malcolm A. S. Moore, Reinhard Henschler, Henschler, Reinhard, Moore, Malcolm A. S., Zheng, Xiaomin   +10 more
core   +2 more sources

Synchronous childhood T-lymphoblastic lymphoma and B-cell precursor acute lymphoblastic leukemia associated with constitutional MMR deficiency syndrome –a case report

Frontiers in Oncology
We present a four-year-old girl with synchronous T-cell lymphoblastic lymphoma (T-LBL) and B-cell precursor acute lymphoblastic leukemia (BCP-ALL).Development of two lymphoid malignancies arising from completely different cell lineages was confirmed by ...
Joanna Bulsa, Agata Karolina Pastorczak, Joanna Taha, Wojciech Mlynarski, Łukasz Sędek, Tomasz Szczepanski   +5 more
doaj   +1 more source

Mosaic chromosomal alterations and relation to haematological cancer in two large Danish cohorts

British Journal of Haematology, EarlyView.
Summary Mosaic chromosomal alterations (mCAs) are large somatic gains, losses and copy‐neutral loss of heterozygosity identified in the peripheral blood, which represent a relatively unexplored spectrum of clonal haematopoiesis. We aimed to describe mCAs in two large Danish cohorts with extensive long‐term registry‐based follow‐up and examine ...
Cecilie Velsoe Maeng, Pei Meng, Mathias Heldbo, Olafur Davidsson, Morten Munk Johansen, Sigrún Thorsteinsdóttir, Jojo Biel‐Nielsen Dietz, Ragnar Pétur Kristjansson, Ole Birger Vesterager Pedersen, Erik Sørensen, Christian Erikstrup, Christina Mikkelsen, Nanna Brøns, Henrik Ullum, Bitten Aagaard, Mie Topholm Bruun, Estrid Høgdall, DBDS Research Consortium, CHB Research Consortium, Bo Porse, Simon Husby, Sisse R. Ostrowski, Henrik Hjalgrim, Kirsten Grønbæk   +23 more
wiley   +1 more source

Gum hypertrophy - an unusual presenting feature in a case of precursor T-cell acute lymphoblastic leukemia

Turkish Journal of Hematology, 2008
Acute lymphoblastic leukemia/lymphoma, the malignant transformation of T-cell or B-cell precursors, is the most common diagnosis in pediatric oncology. Precursor T-cell acute lymphoblastic leukemia/lymphoma commonly affects adolescents, and is associated
Lingappa Appaji, Rudramurthy Pradeep, Vishweshwariah Lakshmidevi, Davanam Satyanarayana Madhumati, Chennagiri Srinivasamurthy Premalata, Geetashree Mukherjee   +5 more
doaj  

Heart failure medication to prevent cancer therapy–related cardiac dysfunction: A narrative review

British Journal of Pharmacology, EarlyView.
Advances in oncological therapies have improved cancer survival but also have increased the clinical incidence of cancer therapy–related cardiac dysfunction (CTRCD), a spectrum of conditions ranging from subclinical biomarker or strain abnormalities to progressive heart failure and cardiogenic shock.
Fabian Voß, Paul Goerke, Malte Kelm, Amin Polzin   +3 more
wiley   +1 more source

A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug l-asparaginase [PDF]

, 2009
l-Asparaginase is a key therapeutic agent for treatment of childhood acute lymphoblastic leukemia (ALL). There is wide individual variation in pharmacokinetics, and little is known about its metabolism.
Vaskar Saha, Krishnan, S., Holland, Mark, Colin Watts, Mark Holland, Holland, M., Liu, JiZhong, Ariffin, Hany, Bates, P.A., Marcin Krol, Paul A. Bates, Moss, Catherine X., Patel, N., Essink, M., Patel, Naina, Clare Dempsey, Krishnan, Shekhar, van Delft, Frederik W., Watts, Colin, Carly Leighton, Leighton, Carly, Eden, T.O.B., Moss, C.X., Offman, Marc N., JiZhong Liu, Dempsey, Clare, Seema Alexander, Hany Ariffin, Bates, Paul A., Dempsey, C., Eden, Tim O B, Alexander, S., van Delft, F.W., Frederik W. van Delft, Watts, C., Offman, M.N., Saha, V., Leighton, C., Eden, Tim O.B., Saha, Vaskar; id_orcid, Shekhar Krishnan, Monika Essink, Saha, Vaskar, Krol, Marcin, Ariffin, H., Tim O.B. Eden, Naina Patel, Alexander, Seema, Catherine X. Moss, Krol, M., Marc N. Offman, Liu, J.Z., Essink, Monika, Van Delft, Frederik W, Offman, Marc N, Bates, Paul A, Moss, Catherine X, Dempsey, Clare E   +57 more
core   +1 more source

Eosinophilia and Hypereosinophilia: A Practical Approach to Navigating a Broad Differential Diagnosis

European Journal of Haematology, EarlyView.
ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley   +1 more source

Blinatumomab for the Treatment of Adult B-Cell Acute Lymphoblastic Leukemia: Toward a New Era of Targeted Immunotherapy

Biologics: Targets & Therapy, 2020
Miguel J Franquiz,1,2 Nicholas J Short2 1Baylor College of Medicine, Houston, TX, USA; 2Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence: Nicholas J ShortDepartment of Leukemia, The University of ...
Franquiz MJ, Short NJ
doaj  

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Cutaneous involvement by myeloid leukaemias: challenging cases with important implications

Histopathology, EarlyView.
Myeloid leukaemias and precursors involving the skin are often challenging to diagnose with varied and overlapping clinical and histopathologic features. Nonetheless, they are critical for pathologists to recognize and accurately classify. This review discusses the clinical, histopathological and genetic features of myelodysplasia cutis (A) and ...
Alexandra C. Hristov
wiley   +1 more source