Results 71 to 80 of about 12,114 (185)
Dysregulated RasGRP1 Responds to Cytokine Receptor Input in T Cell Leukemogenesis [PDF]
, 2012 Enhanced signaling by the small guanosine triphosphatase Ras is common in T cell acute lymphoblastic leukemia/lymphoma (T-ALL), but the underlying mechanisms are unclear. We identified the guanine nucleotide exchange factor RasGRP1 (Rasgrp1 in mice) as a
Ammon, Kristin +17 more
core +1 more source
Bioengineered Extracellular Vesicles in Emerging Cancer Vaccine Platforms
Small Science, EarlyView.This review highlights recent advances in engineering extracellular vesicles (EVs) as next‐generation cancer vaccines. It outlines their biological roles and antigen‐presenting capacity, explores key strategies for antigen loading and delivery optimization, and summarizes preclinical and clinical applications using EVs from diverse immune and tumor ...
Wonkyung Ahn +4 more
wiley +1 more source
ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms [PDF]
, 2019 ZEB1 and ZEB2 are structurally related E-box binding homeobox transcription factors that induce epithelial to mesenchymal transitions during development and disease.
Berx, Geert +12 more
core +3 more sources
British Journal of Haematology, EarlyView.Childhood acute lymphoblastic leukaemia (chALL) remains the most prevalent malignancy in children and adolescents. Improving risk stratification and providing personalized prognosis and treatment remain major clinical challenges. NEAT1 lncRNA overexpression constitutes a powerful, independent predictor of poor treatment outcomes and disease progression
Marieta Xagorari +13 more
wiley +1 more source
Clinical Pediatric Hematology-Oncology, 2023 Patients with chronic myeloid leukemia (CML) in lymphoid blast phase can present clinical characteristics resembling Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).
Tae Hoon Lee +4 more
doaj +1 more source
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Introduction The clinical diagnosis of hematological diseases depends on the differential count of nucleated cells on the bone marrow (BM) smears, and an artificial intelligence (AI)‐based system was applied to automatically classify BM nucleated cells in pediatric hematological disease samples in this study.
Xin He +6 more
wiley +1 more source
Flow Cytometry in the Differential Diagnosis of Lymphocyte-Rich Thymoma From Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma [PDF]
, 2004 Shiyong Li +3 more
openalex +2 more sources
High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-acute lymphoblastic leukemia [PDF]
, 2016 Table S4. Complete list of signaling pathways dysregulated in patients who achieved complete remission therapy. Signaling pathway analysis was done using MetaCore KPA using the set of 442 genes differentially expressed between good and poor response ...
Alba L. Combita +13 more
core +6 more sources
International Journal of Cancer, Volume 157, Issue 12, Page 2447-2454, 15 December 2025.What's New? Investigating the spectrum of (likely) pathogenic germline variants (LP/PVs) in hereditary breast and ovarian cancer (HBOC) genes in pediatric malignancies by unselected genotyping identified 44% (12/27) of clinically unsuspected cases. Burden testing demonstrated considerable associations between monoallelic LP/PVs in five HBOC genes and ...
Katharina Daugs +11 more
wiley +1 more source
MicroRNAs in B cell development and malignancy [PDF]
, 2012 MicroRNAs are small RNA molecules that regulate gene expression and play critical roles in B cell development and malignancy. miRNA expression is important globally, as B cell specific knockouts of Dicer show profound defects in B cell development; and ...
Fernando, Thilini R. +2 more
core +4 more sources