Results 41 to 50 of about 14,408,725 (200)
Single-nucleus RNA sequencing illuminates a functional analog of lymphoid organ in crustacean
Journal of Advanced ResearchIntroduction: The evolution of lymphoid organs is a complex topic in the animal kingdom. A presumptive invertebrate lymphoid organ (Oka) was previously reported in shrimp based on its morphological and histological observations. However, whether it truly
Mingzhe Sun +3 more
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Functional Assessment of αEβ7/E-cadherin Interactions in the Steady State Postnatal Thymus
Clinical and Developmental Immunology, 2004 T cell differentiation in the thymus depends on sequential interactions between lymphoid progenitors and stromal cells in discrete regions of the cortex.
Susan E. Prockop, Howard T. Petrie
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NK Cell Precursors in Human Bone Marrow in Health and Inflammation
Frontiers in Immunology, 2019 NK cells are generated from hematopoietic stem cells (HSC) residing in the bone marrow (BM), similar to other blood cells. Development toward mature NK cells occurs largely outside the BM through travel of CD34+ and other progenitor intermediates toward ...
Federica Bozzano +5 more
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Frontiers in Immunology, 2023 T cells develop from multipotent progenitors by a gradual process dependent on intrathymic Notch signaling and coupled with extensive proliferation. The stages leading them to T-cell lineage commitment are well characterized by single-cell and bulk RNA ...
Boyoung Shin, Ellen V. Rothenberg
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Immunology Letters, 2016 B cells are known to control CD4 T cell differentiation in secondary lymphoid tissues. We hypothesized that IL-10 expression by marginal zone precursor (MZP) regulatory B cells controls the differentiation and positioning of effector and regulatory T ...
G. Lal +10 more
semanticscholar +1 more source
Autophagy in the thymic epithelium is dispensable for the development of self-tolerance in a novel mouse model. [PDF]
PLoS ONE, 2012 The thymic epithelium plays critical roles in the positive and negative selection of T cells. Recently, it was proposed that autophagy in thymic epithelial cells is essential for the induction of T cell tolerance to self antigens and thus for the ...
Supawadee Sukseree +7 more
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Oxidative Stress and Inflammation in B-Cell Lymphomas
Antioxidants, 2023 Mature lymphoid neoplasms arise de novo or by the transformation of more indolent lymphomas in a process that relies on the stepwise accumulation of genomic and transcriptomic alterations.
Mário Sousa-Pimenta +4 more
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Global transcriptome analysis of T-competent progenitors in the bone marrow
Genomics Data, 2015 T cells are known to develop in the thymus. However, molecular events that control the transition from hematopoietic progenitor cells in the bone marrow to T precursor cells seeded in the thymus remained poorly defined.
Vionnie W.C. Yu, David T. Scadden
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Frontiers in Immunology, 2023 The functional relevance of K+ and Ca2+ ion channels in the “Store Operated Calcium Entry” (SOCE) during B and T lymphocyte activation is well proven. However, their role in the process of T- and B- cell development and selection is still poorly defined.
Cesare Sala +6 more
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Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation [PDF]
, 2007 TCR signal strength is involved in many cell fate decisions in the T-cell lineage. Here, we show that transcriptional events induced by Hedgehog (Hh) signaling reduced TCR signal strength in mice.
Drakopoulou, E +7 more
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