Results 31 to 40 of about 104,139 (265)
Functional Assessment of αEβ7/E-cadherin Interactions in the Steady State Postnatal Thymus
Clinical and Developmental Immunology, 2004 T cell differentiation in the thymus depends on sequential interactions between lymphoid progenitors and stromal cells in discrete regions of the cortex.
Susan E. Prockop, Howard T. Petrie
doaj +1 more source
Autophagy in the thymic epithelium is dispensable for the development of self-tolerance in a novel mouse model. [PDF]
PLoS ONE, 2012 The thymic epithelium plays critical roles in the positive and negative selection of T cells. Recently, it was proposed that autophagy in thymic epithelial cells is essential for the induction of T cell tolerance to self antigens and thus for the ...
Supawadee Sukseree +7 more
doaj +1 more source
Oxidative Stress and Inflammation in B-Cell Lymphomas
Antioxidants, 2023 Mature lymphoid neoplasms arise de novo or by the transformation of more indolent lymphomas in a process that relies on the stepwise accumulation of genomic and transcriptomic alterations.
Mário Sousa-Pimenta +4 more
doaj +1 more source
Chimerism after organ transplantation [PDF]
, 1997 Recent evidence suggests that passenger leukocytes migrate after organ transplantation and produce persistent chimerism, which is essential for sustained survival of the allograft.
Demetris, AJ +6 more
core +1 more source
Frontiers in Immunology, 2023 The functional relevance of K+ and Ca2+ ion channels in the “Store Operated Calcium Entry” (SOCE) during B and T lymphocyte activation is well proven. However, their role in the process of T- and B- cell development and selection is still poorly defined.
Cesare Sala +6 more
doaj +1 more source
Sequential induction of NF-κB/Rel family proteins during B-cell terminal differentiation [PDF]
, 1994 The NF-kappa B/Rel family of at least five transcription factor polypeptides is thought to function both as a developmental regulator in B cells and as a rapid response system in all cells. To examine this notion in more detail, we determined the protein
Baltimore, David +3 more
core +1 more source
Global transcriptome analysis of T-competent progenitors in the bone marrow
Genomics Data, 2015 T cells are known to develop in the thymus. However, molecular events that control the transition from hematopoietic progenitor cells in the bone marrow to T precursor cells seeded in the thymus remained poorly defined.
Vionnie W.C. Yu, David T. Scadden
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Frontiers in Immunology, 2016 CD8+ T cells play an important role in host resistance to many viral infections, but the underlying transcriptional mechanisms governing their differentiation and functionality remain poorly defined.
Georges Abboud +8 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source