Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization. [PDF]
PLoS ONE, 2011 Dendritic cells (DCs) subsets differ in precursor cell of origin, functional properties, requirements for growth factors, and dependence on transcription factors.
Brian T Edelson +9 more
doaj +1 more source
Distinct Mechanisms Regulate IL1B Gene Transcription In Lymphoid CD4 T Cells and Monocytes
Cytokine, 2018 Graphical abstract Figure. No caption available. HighlightsTCR activation induces IL1B gene transcription in CD4 T cells.Unlike monocytes, IL1B in T cells is independent of critical myeloid Spi1 protein.Spi1 binding site on IL1B promoter is blocked by a ...
S. Pulugulla +8 more
semanticscholar +1 more source
Comparative study of hematopoietic differentiation between human embryonic stem cell lines. [PDF]
PLoS ONE, 2011 Directed differentiation of human embryonic stem cells (hESCs) into any desired cell type has been hailed as a therapeutic promise to cure many human diseases.
Heather Melichar +7 more
doaj +1 more source
Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue [PDF]
, 2011 The upper respiratory tract mucosa is the location for commensal Streptococcus (S.) pneumoniae colonization and therefore represents a major site of contact between host and bacteria.
Mitchell, T.J. +28 more
core +1 more source
T-BET and EOMES sustain mature human NK cell identity and antitumor function
The Journal of Clinical Investigation, 2023 Since the T-box transcription factors (TFs) T-BET and EOMES are necessary for initiation of NK cell development, their ongoing requirement for mature NK cell homeostasis, function, and molecular programming remains unclear.
Pamela Wong +27 more
doaj +1 more source
Journal of Experimental Medicine, 2010 CD4+CD25+ regulatory T cells (T reg cells) expressing the transcription factor Foxp3 can be induced from peripheral T cell receptor (TCR) transgenic CD4+CD25−Foxp3− T cells stimulated with noninflammatory dendritic cells presenting low amounts of agonist
S. Schallenberg +3 more
semanticscholar +1 more source
Tissue regulatory T cells: regulatory chameleons
Nature reviews. Immunology, 2021 The FOXP3+CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have distinct transcriptomes, T cell receptor repertoires and growth and survival factor ...
A. Muñoz-Rojas, D. Mathis
semanticscholar +1 more source
Interaction of vascular endothelial cells with CD8+ T-cells in vivo [PDF]
, 2008 Transplantation of organs and cells saves and prolongs thousands of lives every year. Surgical techniques were significantly improved but major problems remain, in particular the host’s immune system.
Bolinger, Beatrice
core +1 more source
Journal of Hematology & Oncology, 2009 Background Cholestatic jaundice as a presenting symptom of Precursor T-lymphoblastic leukemia (T-ALL)/lymphoma (T-LBL) has never been reported in literature. Similarly, precursor T-ALL/T-LBL is characteristically negative for synaptophysin. We report the
Latif Sahibzada U +2 more
doaj +1 more source
The transcription factor GATA3 controls cell fate and maintenance of type 2 innate lymphoid cells
Immunity, 2012 Innate lymphoid cells (ILCs) reside at mucosal surfaces and control immunity to intestinal infections. Type 2 innate lymphoid cells (ILC2) produce cytokines such as IL-5 and IL-13 and are required for immune defense against helminth infections and are ...
T. Hoyler +8 more
semanticscholar +1 more source